急性腎盂腎炎應用左氧氟沙星的臨床干預效果分析

王連芹++郭延紅

1.齊魯工業大學校醫院全科門診，山東濟南 250353；2.濟南市槐蔭區吳家堡計劃生育服務站計劃生育科，山東濟南 250118

[摘要]目的 觀察急性腎盂腎炎應用左氧氟沙星的臨床干預效果。 方法 將我院2010年4月～2013年11月確診并收治的110例急性腎盂腎炎患者隨機分為臨床組和參照組各55例。臨床組應用左氧氟沙星靜脈滴注進而口服治療，參照組應用氨芐青霉素靜脈滴注治療進而用磺胺甲惡唑口服治療。比照兩組癥狀體征消失時間、臨床療效及治療時間。 結果 兩組用藥完成后，癥狀體征逐漸改善，臨床組其癥狀體征消失速度均顯著好于參照組，差異有統計學意義（P<0.05）。臨床組總有效率為98.18%，參照組為96.36%，兩組比較差異無統計學意義（P>0.05）。但臨床組其平均治療時長顯著低于參照組，差異有統計學意義（P<0.05）。臨床組1例發生惡心、嘔吐，1例頭暈，1例皮膚瘙癢；參照組4例發生惡心、嘔吐。兩組相比不良反應率差異無統計學意義（P>0.05）。 結論 急性腎盂腎炎應用左氧氟沙星療效確切，迅速緩解癥狀體征、療程短、安全性好。

[關鍵詞]急性腎盂腎炎；左氧氟沙星；氟喹諾酮

[中圖分類號] R692.7 [文獻標識碼] B [文章編號] 2095-0616（2014）16-61-03

Analysis of clinical intervention effects of levofloxacin on acute pyelonephritis

WANG Lianqin1 GUO Yanhong2

1.Outpatient Department of General Practice， School Infirmary of Qilu Industrial University， Ji'nan 250353， China； 2. Department of Family Planning， Huaiyin District Wujiapu Family Planning Service Stations of Ji'nan City， Ji'nan 250118， China

[Abstract] Objective To investigate the clinical intervention effects of levofloxacin on acute pyelonephritis. Methods 110 patients with acute pyelonephritis who were treated in our hospital from April 2010 to November 2013 were randomly divided into the clinical group and the reference group， with 55 patients in each group. The clinical group received intravenous drip of levofloxacin and then oral administration； The reference group received intravenous drip of penbritin and then oral administration of sulfamethoxazole. The symptom and sign disappearance time， clinical efficacy and treatment time of the two groups were compared. Results After the end of medication， the symptoms and sings improved gradually. The clinical group was significantly better than the reference group in both symptom and sign disappearance time， with statistically significant differences （P<0.05）. The total effective rate of the clinical group was 98.18% and that of the reference group was 96.36%， with no statistically significant difference between the two groups （P>0.05）. But the clinical group had significantly shorter average treatment duration than the reference group （P<0.05）， with statistically significant difference. In the clinical group， 1 patient had nausea and vomiting， 1 patient had dizziness， and 1 patient had skin itch； In the reference group， 4 patients had nausea and vomiting. The two groups were not significantly different in the incidence of adverse reactions （P>0.05）. Conclusion In the treatment of acute pyelonephritis， the application of levofloxacin shows accurate efficacy， relieves symptoms and signs rapidly， and has short treatment course and good safety.endprint