不同頻率同時(shí)單采血小板和新鮮冰凍血漿制備的冷沉淀質(zhì)量比較

龐婷婷 陳紹鵬 譚鯤

[摘要]目的通過探討不同頻率同時(shí)單采血小板和新鮮冰凍血漿制備的冷沉淀質(zhì)量比較，探討采血間隔期設(shè)置是否科學(xué)。方法隨機(jī)選取湛江市中心血站2019年1月至2020年1月獻(xiàn)血者800例，根據(jù)首次和連續(xù)多次兩個(gè)月、一個(gè)月、半個(gè)月一次同時(shí)單采血小板和新鮮冰凍血漿分為四組，每組各200例，檢測其單采新鮮冰凍血漿制備成冷沉淀后的Ⅷ因子和纖維蛋白原（FIB）含量，觀察Ⅷ因子、FIB 含量不合格率，并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果一個(gè)月一次、半個(gè)月一次的Ⅷ因子和 FIB 含量明顯低于首次對照組、兩個(gè)月一次，差異有統(tǒng)計(jì)學(xué)意義（ P <0.05），兩個(gè)月一次與首次對照組比較，差異無統(tǒng)計(jì)學(xué)意義（ P >0.05）;一個(gè)月一次、半個(gè)月一次Ⅷ因子含量不合格率與首次對照組比較，差異有統(tǒng)計(jì)學(xué)意義（ P <0.01），半個(gè)月一次的 FIB 含量不合格率與首次對照組比較，差異有統(tǒng)計(jì)學(xué)意義（ P <0.01），其余頻率采集Ⅷ因子、FIB 含量不合格率與首次對照組比較，差異無統(tǒng)計(jì)學(xué)意義（ P >0.05）。結(jié)論不同頻率同時(shí)單采血小板采集血漿制備冷沉淀的質(zhì)量存在差異，一個(gè)月或半個(gè)月一次捐獻(xiàn)后制備冷沉淀的Ⅷ因子含量較質(zhì)量標(biāo)準(zhǔn)有明顯差異。一個(gè)月、半個(gè)月一次單采血小板獻(xiàn)血者不建議其同時(shí)捐獻(xiàn)新鮮冰凍血漿，避免對獻(xiàn)血者健康造成影響。

[關(guān)鍵詞]單采血小板;新鮮冰凍血漿;Ⅷ因子;纖維蛋白原

[中圖分類號] R457? [文獻(xiàn)標(biāo)識(shí)碼] A?? [文章編號]2095-0616（2021）24-0015-03

Quality comparison of cryoprecipitate prepared by simultaneous apheresis platelet and fresh frozen plasma at different frequencies

PANG? Tingting??? CHEN? Shaopeng??? TAN? Kun

Department of Quality Control， Zhanjiang Blood Center， Guangdong， Zhanjiang 524002， China

[Abstract] Objective To compare the quality of cryoprecipitate prepared by collecting fresh frozen plasma from apheresis platelets with different frequencies， and to explore the scientificity of the interval setting of blood collection. Methods A total of 800 blood donors were randomly selected from January 2019 to January 2020 in Zhanjiang Blood Center， and they were divided into four groups according to the first and continuous collection of platelets and fresh frozen plasma for once every two months， one month and half a month， with 200 people in each group. The content of factor Ⅷ and fibrinogen （FIB） was detected after cryoprecipitate was prepared from fresh frozen plasma， observe the unqualified rate of factor Ⅷ and FIB content. The statistical analysis was conducted. Results The Ⅷ factor and FIB content of once a month and half a month was significantly lower than that of the first control group and once every two months， the difference was statistically significant （P <0.05）， but there was no significant difference between once every two months and the first control group （P >0.05）.Once a month and a half month Ⅷ fraction defective is compared with the first control group was statistically significant （P <0.01）， a half month FIB content is not qualified rate compared with the first control group was statistically significant （P <0.01）， the rest of the frequency acquisition Ⅷ factor， fraction defective FIB content compared with the first control group without statistical significance （P >0.05）. Conclusion There are differences in the quality of cryoprecipitate prepared by collecting plasma from platelets at different frequencies， and the content of factor Ⅷ in cryoprecipitate prepared by donating once a month or half a month is significantly different from the quality standard. Blood donors who collect platelets once a month or half a month are not recommended to donate fresh frozen plasma at the same time， so as to avoid affecting the health of blood donors.

[Key words] Apheresis platelets; Fresh frozen plasma; Factor Ⅷ; Fibrinogen

成分輸血是目前最經(jīng)濟(jì)有效的臨床治療手段，血小板制品對因血小板數(shù)量減少或功能異常而導(dǎo)致出血的患者具有較好的療效，血細(xì)胞分離機(jī)單采血小板可以提高血小板的采集數(shù)量與質(zhì)量、降低紅細(xì)胞的浪費(fèi)、減少獻(xiàn)血人數(shù)，降低輸血傳播疾病的概率和輸血反應(yīng)率[1-3]。血細(xì)胞分離機(jī)是根據(jù)血細(xì)胞比重不同先分離出血漿再進(jìn)一步分離出血小板，單采血小板獻(xiàn)血者可以同時(shí)捐獻(xiàn)血漿，血漿制備的冷沉淀主要含有Ⅷ因子和纖維蛋白原（FIB）?！?br>