吸入激素聯合噻托溴銨治療哮喘—慢阻肺重疊綜合癥的臨床療效探究

劉元君

摘要：目的：探討分析吸入激素聯合噻托溴銨治療哮喘-慢阻肺重疊綜合癥的臨床療效。方法：選取我站2015年1月至2017年11月收治的102例哮喘-慢阻肺重疊綜合癥患者，隨機平均分為對照組和研究組，給予對照組患者糖皮質激素吸入治療，給予研究組患者吸入激素聯合噻托溴銨治療，對比分析兩組患者治療效果。結果：在給予兩組患者不同治療干預措施之后，研究組患者第一秒用力呼氣量，最大肺活量，一氧化碳彌散量，吸氣分數，殘總比等指標顯著優于對照組，P<0.05；研究組患者癥狀評分顯著高于對照組，P<0.05。結論：在治療哮喘-慢阻肺重疊綜合癥患者時采用吸入激素聯合噻托溴銨治療干預具有顯著效果，能夠改善患者肺功能和疾病癥狀，因此值得推廣使用。

關鍵詞：吸入激素；噻托溴銨；哮喘-慢阻肺重疊綜合癥；臨床療效

Abstract：Objective：To investigate the clinical efficacy of inhaled steroid combined with tiotropium in the treatment of asthma-slow lung obstruction syndrome. METHODS：A total of 102 patients with asthma-stable lung obstruction syndrome who were admitted to our station from January 2015 to November 2017 were randomly divided into the control group and the study group. The glucocorticoid inhalation therapy was given to the control group. The patients were treated with inhaled steroids combined with tiotropium bromide，and the therapeutic effects of the two groups were compared. RESULTS：After giving different treatment interventions to the two groups，the first-second forced expiratory volume，maximum vital capacity，carbon monoxide diffusion，inspiratory fraction，and residual ratio were significantly better in the study group than in the control group，P < 0.05；The symptom score of the study group was significantly higher than that of the control group，P < 0.05. Conclusion：The use of inhaled steroids combined with tiotropium in the treatment of patients with asthma-slow lung obstruction syndrome has significant effects and can improve lung function and disease symptoms，so it is worth promoting.

Key words：inhaled hormone；tiotropium bromide；asthma-chronic obstructive pulmonary overlap syndrome；clinical efficacy

慢性阻塞性肺疾病和支氣管哮喘疾病均屬于常見呼吸疾病，由于氣道慢性炎癥會導致患者細支氣管阻塞癥狀出現，使其出現呼吸受限、呼吸困難以及咳嗽咳痰等癥狀。按照相關研究文獻顯示，慢性阻塞性肺疾病和支氣管哮喘在發病原因，臨床癥狀，誘發因素等均存在重疊性，此時就會導致患者出現哮喘-慢阻肺重疊綜合癥[1]。此次研究主要是探討分析吸入激素聯合噻托溴銨治療哮喘-慢阻肺重疊綜合癥的臨床療效，現將資料報告如下：

1 資料與方法

1.1一般資料

選取我站2015年1月至2017年11月收治的102例哮喘-慢阻肺重疊綜合癥患者，隨機平均分為對照組和研究組各51例。……