吳少文 馬劍鋒 林欣庚
【摘要】 目的:研究和分析下呼吸道感染應(yīng)用頭孢曲松與頭孢克肟序貫治療的療效。方法:選取本院2015年3月-2017年2月收治的下呼吸道感染患者100例為對象進(jìn)行研究,根據(jù)機隨機數(shù)字法將其分為對照組與觀察組,每組各50例。對照組患者采用頭孢曲松治療,觀察組在此基礎(chǔ)上再結(jié)合頭孢克肟序貫治療。觀察對比兩組患者臨床療效。結(jié)果:經(jīng)治療,觀察組痊愈27例、顯效13例、有效8例、無效2例,治療總有效率為96.0%(48/50),而對照組痊愈20例、顯效14例、有效7例、無效9例,治療總有效率為82.0%(41/50),觀察組臨床療效顯著優(yōu)于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論:下呼吸道感染應(yīng)用頭孢曲松與頭孢克肟序貫治療后效果十分顯著,且具有較高的安全性、可靠性,因此值得應(yīng)用于臨床推廣。
【關(guān)鍵詞】 下呼吸道感染; 頭孢曲松; 頭孢克肟; 序貫治療; 療效分析
Efficacy Analysis of Sequential Therapy of Ceftriaxone and Cefixime in Patients with Lower Respiratory Tract Infection/WU Shao-wen,MA Jian-feng,LIN Xin-geng.//Medical Innovation of China,2017,14(22):125-127
【Abstract】 Objective:To study the curative effect and analysis of treatment with Ceftriaxone and Cefixime sequential therapy of lower respiratory tract infection.Method:100 patients with lower respiratory tract infection in our hospital were selected from March 2015 to February 2017 as the study objects,according the randomly number table method,they were divided into control group and observation group,50 cases in each group.The control group was treated with Ceftriaxone treatment,the observation group combined Cefixime sequential therapy based on control group.The clinical efficacy of the two groups were observed.Result:After treatment,in observation group 27 cases were cured,13 cases of markedly effective,8 cases of effective,2 cases of invalid,the total effective rate was 96.0%(48/50);in control group,20 cases were cured,14 cases of markedly effective,7 cases of effective,9 cases of ineffective,the total effective rate was 82.0%(41/50),the clinical curative effect of observation group was significantly better than the control group,the difference was statistically significant(P<0.05).Conclusion:Lower respiratory tract infection with ceftriaxone and cefotaxime cefixime sequential therapy effect is very significant,safety,and high reliability,so it is worthy of clinical application and promotion.
【Key words】 Lower respiratory tract infection; Ceftriaxone; Cefixime; Sequential therapy; Curative effect analysis
First-authors address:Puning Peoples Hospital,Puning 515300,China
doi:10.3969/j.issn.1674-4985.2017.22.037
下呼吸道感染是臨床上最常見的感染性疾病,其指的是喉部支氣管間發(fā)生的急性炎癥,通常表現(xiàn)為肺炎、支氣管炎以及急性氣管炎等。下呼吸道感染具有相對較高的發(fā)病率以及較強的傳染性,且以春秋季節(jié)為發(fā)病的高峰[1-3]。目前在治療下呼吸道感染患者的過程中,主要采用的藥物為抗菌消炎類。而作為第三代頭孢菌素類抗生素,頭孢克肟、頭孢曲松具有較廣的抗菌譜,較高的生物利用度以及相對較長的半衰期,因此將其應(yīng)用于下呼吸道感染患者治療后效果較為良好[4-5]。序貫治療指的是采用具有較高生物利用度以及較長半衰期的藥物,治療時先采用注射劑,然后將注射劑采用口服劑進(jìn)行替代治療,這種轉(zhuǎn)換只發(fā)生于同種藥物的不同劑型之間[6-8]。……