陳沂 王麗杰 石偉奇 馬秀華
【摘要】 目的:對379例妊娠期高血壓疾病患者的臨床資料進行回顧性分析,了解其發(fā)病情況、臨床特點以及對孕產(chǎn)婦和圍產(chǎn)兒的影響,為臨床防治提供相關(guān)依據(jù)。方法:收集2016年1月1日-12月31日在本院婦產(chǎn)科住院、分娩孕周≥28周的379例妊娠期高血壓疾病患者的相關(guān)臨床資料,包括孕婦年齡、孕產(chǎn)次、住院天數(shù)、分娩方式、母嬰并發(fā)癥、妊娠結(jié)局及部分生化指標,并進行統(tǒng)計學分析。結(jié)果:妊娠期高血壓疾病的發(fā)病率是5.13%(379/7395),其中子癇前期的發(fā)病率是2.68%(198/7395)。雙胎妊娠和孕期體重增長過多是發(fā)生子癇前期的高危因素。妊娠期高血壓組、輕度子癇前期組和重度子癇前期組,隨著病情的進展,各組孕周縮短、剖宮產(chǎn)比例升高,新生兒出生體重降低,胎兒宮內(nèi)生長受限、胎兒窘迫的發(fā)生率增高,比較差異有統(tǒng)計學意義(P<0.05)。血清乳酸脫氫酶、尿酸水平和妊娠期高血壓疾病病情的嚴重程度呈正相關(guān),而高密度脂蛋白膽固醇水平與之呈負相關(guān),比較差異均有統(tǒng)計學意義(P<0.01)。結(jié)論:對于妊娠期高血壓疾病,要加強對高危因素的干預,重視孕婦和胎兒的監(jiān)測,適時終止妊娠,以改善妊娠結(jié)局。
【關(guān)鍵詞】 妊娠期高血壓疾病; 子癇前期; 臨床分析
Clinical Analysis of the 379 Patients with Hypertensive Disorders of Pregnancy/CHEN Yi,WANG Li-jie,SHI Wei-qi,et al.//Medical Innovation of China,2017,14(22):051-055
【Abstract】 Objective:To investigate the clinical incidence,features,complication and pregnancy outcome of patients of hypertensive disorders of pregnancy(HDP).Method:Clinical data of 379 women with HDP admitted in Beijing Daxing District Peoples Hospital from January 1 to December 31 in 2016,whose gestational weeks ≥28.The general information,complications,outcome,delivery mode,several biochemical markers and perinatal complications of newborns were documented.Result:The incidence rate of HDP was 5.13%(379/7395),the incidence rate of preeclampsia was 2.68%(198/7395).Twin pregnancy and exceeded gestational weight gain were the risk factors of HDP.With the progress of disorder,the gestational weeks were shortened,the proportion of cesarean section increased and neonatal weight decreased,the incidence rate of fetal growth restriction and fetal distress were increased(P<0.05).The serum level of lactate dehydrogenase and uric acid was positively correlated with the severity of HDP,respectively;but the level of high density lipoprotein cholesferol was negatively correlated with it(P<0.01).Conclusion:For pregnant women with HDP,increased intervention to high-risk factors,closely monitoring clinical symptoms and timely termination of pregnancy would reduce the incidence of serious complications and improve the prognosis of perinatal infants.
【Key words】 Hypertensive disorders of pregnancy; Preeclampsia; Clinical analysis
First-authors address:Peoples Hospital of Beijing Daxing District,Beijing 102600,China
doi:10.3969/j.issn.1674-4985.2017.22.015
妊娠期高血壓疾病(hypertensive disorders of pregnancy,HDP)是妊娠期的常見疾病,是導致孕產(chǎn)婦和圍產(chǎn)兒發(fā)病率與死亡率增高的重要原因之一。我國HDP的發(fā)生率為5%~12%,而全球因HDP造成的孕產(chǎn)婦死亡數(shù)約占孕產(chǎn)婦死亡總數(shù)的10%~16%[1-2]。本研究對北京市大興區(qū)人民醫(yī)院婦產(chǎn)科保健的HDP患者的臨床資料進行回顧性分析,旨在了解HDP的發(fā)病情況、臨床特點以及對孕產(chǎn)婦和圍產(chǎn)兒的影響,為臨床防治HDP提供相關(guān)依據(jù)。endprint
1 資料與方法
1.1 一般資料 選擇2016年1月1日-12月31日在本院婦產(chǎn)科住院、分娩孕周≥28周、符合妊娠期高血壓疾病診斷標準的患者379例,收集其相關(guān)的臨床資料,包括孕婦年齡、孕產(chǎn)次、住院天數(shù)、分娩方式、母嬰并發(fā)癥、妊娠結(jié)局及部分生化指標。……