激素替代治療對(duì)圍絕經(jīng)期綜合征婦女子宮內(nèi)膜厚度和激素水平的影響分析

李丹妍

【摘要】 目的：分析圍絕經(jīng)期綜合征婦女接受激素替代治療對(duì)其子宮內(nèi)膜厚度和激素水平的影響。方法：隨機(jī)選擇2015年1月-2016年12月在本院接受治療的圍絕經(jīng)期綜合征婦女84例，采用隨機(jī)數(shù)字表法分為觀察組對(duì)照組，每組42例。對(duì)照組利用谷維素單獨(dú)治療，觀察組選擇補(bǔ)佳樂(lè)、安宮黃體酮以及達(dá)英-35治療，比較兩組治療效果。結(jié)果：觀察組治療后各項(xiàng)激素指標(biāo)水平均優(yōu)于對(duì)照組，癥狀評(píng)分結(jié)果低于對(duì)照組，子宮內(nèi)膜厚度高于對(duì)照組，焦慮、抑郁評(píng)分均低于對(duì)照組，差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：圍絕經(jīng)期綜合征婦女接受激素替代治療可以增加子宮內(nèi)膜厚度，促使機(jī)體激素水平得以有效改善，使患者臨床癥狀得到更有效緩解，值得廣泛應(yīng)用。

【關(guān)鍵詞】 圍絕經(jīng)期綜合征； 激素替代； 子宮內(nèi)膜厚度； 激素水平

Effect of Hormone Replacement Therapy on Endometrial Thickness and Hormone Levels in Women with Perimenopausal Syndrome/LI Dan-yan.//Medical Innovation of China，2017，14（22）：032-035

【Abstract】 Objective：To analyze the effect of hormone replacement therapy on endometrial thickness and hormone levels in perimenopausal women.Method：From January 2015 to December 2016，84 cases of perimenopausal syndrome women treated in our hospital were selected，and divided into observation group and control group according to the random number table method，the control group adopted Oryzanol treatment only，the observation group adopted Medroxyprogesterone acetate and Estradiol valerate and Diane-35 treatment，the treatment effects of two groups were compared. Result：After treatment，the level of various hormone index of the observation group were better than those of the control group.the symptom score of the observation group was lower than that of the control group，the endometrial thickness of the observation group was higher than that of the control group，the anxiety and depression scores of the observation group were lower than those of the control group，the differences were statistically significant（P<0.05）.Conclusion：Perimenopausal syndrome women adopt hormone replacement therapy，can increase the endometrial thickness，improve the body hormone level effectively，and relief the clinical symptoms of the patients，it is worthy of widely application.

【Key words】 Perimenopausal syndrome； Hormone replacement； Endometrial thickness； Hormone levels

First-authors address： The Second Affiliated Hospital of Medical College of Shantou University，Shantou 515000，China

doi：10.3969/j.issn.1674-4985.2017.22.009

本研究具體分析2015年1月-2016年12月本院收治的圍絕經(jīng)期綜合征患者經(jīng)激素替代治療后的臨床效果，評(píng)價(jià)性激素治療對(duì)患者子宮內(nèi)膜厚度和激素水平的影響，現(xiàn)報(bào)道如下。

1 資料與方法

1.1 一般資料 選取本院在2015年1月-2016年12月84例圍絕經(jīng)期綜合征患者進(jìn)行研究，（1）納入標(biāo)準(zhǔn)：血雌二醇（E2）<30 pg/mL，促卵泡激素（FSH）>20 IU/L；3個(gè)月內(nèi)未使用過(guò)性激素類(lèi)藥物；Kupperman Index量表（KI）評(píng)分≥10分，且其中有一項(xiàng)癥狀≥2分[1]。（2）排除標(biāo)準(zhǔn)：不明原因的子宮內(nèi)膜增生或是陰道流血；半年內(nèi)出現(xiàn)活動(dòng)性靜、動(dòng)脈血栓栓塞性疾病；乳腺癌；嚴(yán)重肝腎功能障礙；系統(tǒng)性紅斑狼瘡、耳硬化癥、血卟啉癥；伴有相關(guān)于性激素的惡性腫瘤；相關(guān)于孕激素的腦膜瘤；妊娠；子宮肌瘤；乳腺癌家族史；糖尿病及嚴(yán)重高血壓；乳腺良性疾病；有血栓栓塞性疾病史或血栓形成傾向；子宮內(nèi)膜異位癥；哮喘、膽囊疾病、高泌乳素血癥、偏頭痛、癲癇[2]。……