膠體金法聯(lián)合檢測糞便中血紅蛋白與轉(zhuǎn)鐵蛋白在鑒別消化道出血中的應(yīng)用

植奇升　劉文彬

【摘要】 目的：探討膠體金法聯(lián)合檢測糞便中血紅蛋白與轉(zhuǎn)鐵蛋白在鑒別消化道出血中的應(yīng)用。方法：回顧性選取2016年5月-2017年4月本院確診治療的消化道出血患者100例為出血組，同期選取無消化道出血人員100例為對照組，采用膠體金法檢測糞便中血紅蛋白與轉(zhuǎn)鐵蛋白水平。結(jié)果：在鑒別消化道出血的敏感度、特異度、準(zhǔn)確度方面，單獨血紅蛋白檢測法分別為76.00%、86.00%、81.00%，單獨轉(zhuǎn)鐵蛋白檢測法分別為80.00%、88.00%、84.00%，二者聯(lián)合檢測時分別為90.00%、96.00%、93.00%，二者聯(lián)合檢測時明顯高于二者單獨檢測，差異均有統(tǒng)計學(xué)意義（P<0.05）；但二者單獨檢測時敏感度、特異度、準(zhǔn)確度比較，差異均無統(tǒng)計學(xué)意義（P>0.05）。結(jié)論：膠體金法檢測糞便中血紅蛋白與轉(zhuǎn)鐵蛋白在鑒別消化道出血中具有良好的敏感度、特異度、準(zhǔn)確度，二者聯(lián)合檢測時可有效提高其鑒別效能，值得臨床作進一步推廣。

【關(guān)鍵詞】 膠體金法； 血紅蛋白； 轉(zhuǎn)鐵蛋白； 鑒別； 消化道出血

Application of Hemoglobin Combined Transferrin Detection in Faeces by Colloidal Gold Method for Identifying of Gastrointestinal Bleeding/ZHI Qi-sheng，LIU Wen-bin.//Medical Innovation of China，2017，14（22）：013-016

【Abstract】 Objective：To discuss the application of hemoglobin combined transferrin detection in faeces by colloidal gold method for identifying gastrointestinal bleeding.Method：From May 2016 to April 2017，100 patients with gastrointestinal bleeding treated in our hospital were selected as bleeding group，and 100 people without gastrointestinal bleeding were selected as control group at the same time，and the faeces hemoglobin and transferrin levels were detected by colloidal gold method.Result：The sensitivity，specificity，accuracy degrees of identifying gastrointestinal bleeding in separate hemoglobin detection were 76.00%，86.00% and 81.00% respectively，which of separate transferrin detection were respectively 80.00%，88.00% and 84.00%，two methods combined detection were 90.00%，96.00% and 93.00% respectively，the sensitivity，specificity，accuracy degrees of combined detection were higher than those of separate detection，the differences were statistically significant（P<0.05），but there were no significant differences between two separate detections（P>0.05）.Conclusion：Hemoglobin combined transferrin detection in faeces by colloidal gold method has good sensitivity，specific，accuracy degree in gastrointestinal bleeding identifying，which can effectively improve the identification efficiency，its worth for further clinical promotion.

【Key words】 Colloidal gold method； Hemoglobin； Transferring； Identifying； Gastrointestinal bleeding

First-authors address：Guangzhou Xinhai Hospital，Guangzhou 510300，China

doi：10.3969/j.issn.1674-4985.2017.22.004

消化道出血是臨床上較為常見的一種消化系統(tǒng)疾病，與消化道本身的炎癥、機械性損傷、血管病變、腫瘤等因素或鄰近器官的病變和全身性疾病累及有關(guān)，嚴(yán)重影響患者的身體健康[1]。目前，消化道出血常用的診斷方法為便隱血檢測，其中膠體金法檢測血紅蛋白與轉(zhuǎn)鐵蛋白是常用的檢測方式，但其單一檢測時，存在較大的局限性，仍有較多的誤診漏診[2-3]。對此，本研究通過膠體金法聯(lián)合檢測糞便中血紅蛋白與轉(zhuǎn)鐵蛋白，探討其在鑒別消化道出血中的應(yīng)用價值，現(xiàn)報道如下。

1 資料與方法endprint

1.1 一般資料 回顧性選取2016年5月-2017年4月本院確診治療的消化道出血患者100例為出血組，同期選取無消化道出血人員100例為對照組。……