代謝綜合征與腫瘤相關性流行病學調查

趙思文　吳君潔　馮婥　張小明

代謝綜合征與腫瘤相關性流行病學調查

趙思文★吳君潔馮婥張小明

［摘要］目的篩查惡性腫瘤，為其病因、發病機制和預防提供科學依據。方法從2013年1月至2014年12月期間在我院體檢人群中隨機抽取6 050例，年齡在20歲～80歲之間，平均年齡（53．0± 3．4）歲。其中男3 826例，女2 224例，男女比為1．7∶l。按代謝綜合征（metaholic syndrome，MS）診斷標準分為MS組與非MS組，MS組再分為腫瘤組與非腫瘤組，比較兩對應組間MS各組分的數據，分析MS各組分與腫瘤發生的相關性。結果符合MS診斷標準986人，患病率為16．3%（986／6 050）。發現腫瘤患者43人，占MS人群4．36%（43／986）。腫瘤組MS各組分明顯高于非腫瘤組（P＜0．05）。腰圍、甘油三脂（triglyceride，TG）、高密度脂蛋白膽固醇（high density lipoprotein cholesterol，HDL-C）和空腹血糖（fasting plasma glucose，FPG）與腫瘤相關（P＜0．01），其中腰圍、TG、和FPG是腫瘤的危險因素，HDL-C是保護因素。結論伴發MS組分可能與腫瘤發展相關。

［關鍵詞］代謝綜合征；腫瘤；流行病學調查

作者單位：廣州醫科大學附屬第二醫院健康體檢中心，廣東，廣州510260

Epidemiological study of relationship between metabolic syndrome and cancers

ZHAO Siwen★, WU Junjie, FENG Chuo, ZHANG Xiaoming
(Physical Examination Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, 510260)

[ABSTRACT] ObjectiveTo provide scientific basis for pathogenesis, mechanism and prevention of related cancers by screening cancers among MS patients.Methods6 050 physical examination persons [ranged from 20 to 80 in age (mean 53.0±3.4 years old)] were selected randomly in our physical examination center from January 2013 to December 2014. Cases were divided into MS group and non-MS group at random according to the criterion of MS. The MS group was divided into cancer group and non-cancer group. MS components in MS group and non-MS group, cancer group and non-cancer group were compared, respectively. And the correlation between cancers and components of MS was evaluated by linear logistic regression analysis.Results986 persons among 6 050 physical examination persons were diagnosed with MS, with the morbidity of 16.3% (986/6 050). 43 persons were diagnosed with cancer, with the morbidity in MS patients of 4.36%(43/986). The measuved values of each component in MS group were higher than those in non-MS group (P<0.05). Logistic regression analysis showed that waist circumference, triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) were correlated with cancers.Waist circumference, TG, and FPG were risk factors for cancer, while HDL-C was a protective factor. Conclusion Concomitant MS components maybe associated with the development of cancers.

［KEY WORDS］Metabolic syndrome；Cancer；Epidemiological studies

代謝綜合征（metabolic syndrome，MS）是一組以胰島素抵抗為核心，表現為中心性肥胖、高血壓、高血脂、高血糖的綜合性疾病。流行病學資料表明MS在健康人群中具有極高的發病率，達到19．5%［1］，芬蘭對老年人群開展調查發現MS患病率男性為35．2%，女性為33．1%［2］，而中國則分別為16．5%和15．8%［3］。

近年來大量流行病學調查顯示MS不僅增加了心腦血管疾病的風險［4］，而且與消化、泌尿、生殖系統等多種惡性腫瘤發生、發展密切相關。本文運用流行病學調查方法，在我院開展體檢人群MS與腫瘤相關的篩查工作，旨在探討兩者間的關系，為病因、發病機制和預防提供科學依據?！?br>