血清胱抑素C與2型糖尿病腎病的相關性研究

熊巍　余江毅

[摘要] 目的 探討2型糖尿病腎病患者腎功能、尿蛋白及代謝指標與血清胱抑素C水平的相關性。方法 選取2017年1—12月收治的244例2型糖尿病腎病患者為研究對象，將研究對象分為早期腎病組、臨床腎病組、終末期腎病組。檢測3組患者空腹血糖（FBG）、空腹C肽、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）、膽固醇（TC）、尿酸（UA）、尿素（BUN）、肌酐（SCr）、血胱抑素C（CysC）、尿白蛋白肌酐比值（UACR），并進行統計學分析。結果 3組間體重指數、TG、HDL水平比較差異無統計學意義（P>0.05），終末期腎病組年齡、血壓、病程、TC、LDL、空腹C肽水平高于早期腎病組，且差異有統計學意義（P<0.05），臨床腎病組、終末期腎病組UA、BUN、SCr、CysC、UACR水平均高于早期腎病組，且差異有統計學意義（P<0.05）。Spearman相關性分析表明CysC與2型糖尿病腎病患者年齡、病程、空腹C肽、UA、BUN、SCr、CysC、UACR呈正相關（P<0.05）。結論 CysC與DN進展具有相關性，有助于DN的早期診斷。

[關鍵詞] 糖尿病腎病;血清胱抑素C;相關性;早期診斷

[中圖分類號] R47? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1672-4062（2019）07（a）-0068-03

Study on the Relationship between Serum Cystatin C and Type 2 Diabetic Nephropathy

XIONG Wei， YU Jiang-yi

The Affiliated Hospital of Nanjing University of Chinese Medicine， Nanjing， Jiangsu Province，210000 China

[Abstract] Objective To investigate the correlation between renal function， urinary protein and metabolic parameters and serum cystatin C level in patients with type 2 diabetic nephropathy. Methods A total of 244 patients with type 2 diabetic nephropathy admitted to our hospital from January to December 2017 were selected as subjects of study. The subjects were divided into early nephropathy group， clinical nephropathy group and end-stage nephropathy group. Fasting blood glucose （FBG）， fasting C-peptide， high density lipoprotein （HDL）， low density lipoprotein（LDL）， triglyceride（TG）， cholesterol （TC）， uric acid （UA）， urea （BUN）， creatinine （SCr）， cystatin C（CysC）， and creatinine ratio of urine albumin （UACR） were measured and analyzed statistically. Results There was no significant difference in body mass index， TG and HDL levels among the three groups（P>0.05）. The levels of age， blood pressure， course of disease， TC， LDL and fasting C-peptide in end-stage nephropathy group were higher than those in early-stage nephropathy group， and the difference was statistically significant（P<0.05）. The levels of UA， BUN， SCr， CysC and UACR in clinical nephropathy group and end-stage nephropathy group were higher than those in early nephropathy group， and the difference was statistically significant（P<0.05）. Spearman correlation analysis showed that CysC was positively correlated with age， course of disease， fasting C-peptide， UA， BUN， SCr， CysC and UACR in patients with type 2 diabetic nephropathy（P<0.05）. Conclusion CysC is correlated with DN progress， which is helpful for early diagnosis of DN.