參芪補肺湯對慢性阻塞性肺疾病穩定期肺氣虛證患者的臨床療效觀察

沈建麗+余藝萍+葉超

【摘要】 目的：研究慢性阻塞性肺疾?。–OPD）穩定期肺氣虛證患者采用參芪補肺湯治療的臨床效果。方法：臨床納入60例2013年8月-2016年8月本院收治的COPD穩定期肺氣虛證患者作為研究對象。按隨機排列表法分為兩組，各30例。其中30例患者采用西醫藥物治療作為對照組，另30例患者在上述基礎上給予參芪補肺湯治療作為觀察組。觀察兩組患者治療效果、肺功能情況、生活質量以及不良反應情況等。結果：觀察組治療總有效率高達96.67%，明顯高于對照組的80.00%（P<0.05）。治療前兩組FVC、FEV1以及FEV1/FVC對比，差異均無統計學意義（P>0.05），治療后觀察組FVC、FEV1以及FEV1/FVC均明顯優于對照組（P<0.05）。治療前兩組ADL、QOL評分比較，差異均無統計學意義（P>0.05），治療后觀察組ADL、QOL評分均高于對照組（P<0.05）。觀察組不良反應發生率僅為10.00%，與對照組的16.67%相比，差異無統計學意義（P>0.05）。結論：對于COPD穩定期患者采用參芪補肺湯治療效果顯著，肺功能改善明顯，生活質量提高，安全可靠，值得臨床應用及推廣。

【關鍵詞】 慢性阻塞性肺疾??； 肺氣虛證； 參芪補肺湯； 穩定期

【Abstract】 Objective：To study the clinical effect of Shenqi Bufei Decoction of TCM in the treatment of Lung Qi deficiency syndrome for stable phase of chronic obstructive pulmonary disease（COPD） patients.Method：60 stable phase of COPD patients complicated with Lung Qi deficiency syndrome treated from August 2013 to August 2016 in our hospital were selected.The subjects were randomly divided into two groups， 30 cases each group.The control group took the western medicine，on the basis of the control group，the observation group also took Shenqi Bufei Decoction of TCM.The clinical effect，pulmonary function，quality of life and adverse reactions of two groups were observed.Result：The total effective rate of the observation group（96.67%） was

significantly higher than that of the control group（80.00%）（P<0.05）.Before treatment，FVC，FEV1 and FEV1/FVC

of two groups were not significantly different（P>0.05），after treatment，FVC，FEV1 and FEV1/FVC of the observation group were significantly better than those of the control group（P<0.05）.Before treatment，ADL points and QOL points of two groups were not significantly different（P>0.05），after treatment，ADL points and QOL points of the observation group were significantly higher than those of the control group（P<0.05）.The adverse event rate of the observation group（10.00%） was not significantly different from the control group（16.67%）（P>0.05）.Conclusion：For stable phase of COPD patients，Shenqi Bufei Decoction of TCM can greatly improve their pulmonary function，quality of life and clinical safety and reliability.It is worthy of clinical application and promotion.

【Key words】 COPD； Lung Qi deficiency syndrome； Shenqi Bufei Decoction of TCM； Stable phase

First-authors address：Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine，Nanchang 330006，China

doi：10.3969/j.issn.1674-4985.2017.29.032

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）是臨床常見的慢性疾病之一，嚴重危害中老年群體[1]。COPD的臨床特征為不完全可逆的氣流受限，呈進展性，若不及時治療，輕則引起肺功能下降，導致氣喘、咳嗽等癥狀出現，重則出現全身反應，已引起專家學者的關注和重視[2-3]。COPD致殘致死率較高，發病率呈逐年上升趨勢，已成為公共衛生問題[4]。目前臨床認為，如何有效阻止肺功能的惡化是治療COPD的關鍵問題。雖然西醫中治療COPD的藥物較多，但僅能延緩疾病的進展，不能有效改善肺功能[5-6]。隨著中醫對COPD研究的進展，國內學者發現采用參芪補肺湯對治療肺氣虛證的COPD患者具有較好效果，但缺乏隨機對照研究和臨床依據[7-8]。因……