探討舍曲林聯合利培酮治療精神分裂癥陰性癥狀的療效和安全性

李少梅+王婉文

【摘要】 目的：探究舍曲林聯合利培酮治療精神分裂癥陰性癥狀的療效和安全性。方法：隨機選取2014年5月-2016年5月本院收治的精神分裂癥患者中116例進行臨床分析，按照隨機數字表法將其分為對照組和探討組，各58例。其中對照組單獨使用利培酮治療，探討組使用舍曲林聯合利培酮治療，觀察統計兩組臨床療效和不良反應發生情況。結果：探討組治療總有效率明顯優于對照組，差異有統計學意義（P<0.05）；治療前，兩組各項陰性癥狀評分比較，差異均無統計學意義（P>0.05）；治療后，探討組各項陰性癥狀評分均低于對照組，差異均有統計學意義（P<0.05）；探討組不良反應發生率為17.24%，對照組為18.97%，兩組比較差異無統計學意義（P>0.05）。結論：針對精神分裂癥陰性癥狀患者而言，可通過舍曲林聯合利培酮治療，效果突出，安全性較高，可推廣使用。

【關鍵詞】 舍曲林； 利培酮； 精神分裂癥； 陰性癥狀； 療效； 安全性

【Abstract】 Objective：To explore the clinical effect and safety of Sertraline combined with Risperidone in the treatment of negative symptoms of schizophrenia.Method：116 cases of schizophrenia and who accepted treatments in our hospital from May 2014 to May 2016 were randomly selected for clinical analysis，they were divided into the control group and the study group according to the law of numerical method，58 cases in each group.The control group was treated with Risperidone alone，while the study group was treated with Sertraline combined with Risperidone.The clinical effects and adverse reactions of two groups were observed and counted.Result：The total of effective rate of the study group was significantly better than that of the control group，the difference was statistically significant（P<0.05）.Before treatment，the scores of negative symptoms of two groups were compared，the differences were not statistically significant（P>0.05）.After treatment，the scores of negative symptoms of the study group were lower than those of the control group，the differences were statistically significant（P<0.05）.The total incidence of adverse reactions of the study group was 17.24%，and the control group was 18.97%，the difference was not statistically significant（P>0.05）.Conclusion：For patients with negative symptoms of schizophrenia，Sertraline can be combined with Risperidone treatment，and the effect is prominent，the safety is high，thus it can be widely used.

【Key words】 Sertraline； Risperidone； Schizophrenia； Negative symptoms； Clinical effect； Safety

First-authors address：Qishan Hospital in Panyu District of Guangzhou City，Guangzhou 511483，China

doi：10.3969/j.issn.1674-4985.2017.29.027

精神分裂癥發病原因具有一定復雜性，與患者突然的情感壓抑以及精神刺激存在密切聯系，主要以行為、思維和情感異常為臨床表現[1-2]。精神分裂癥根據癥狀可分為陰性和陽性癥狀，其中陽性癥狀給予合理治療可明顯改善，而陰性癥狀由于相對隱秘難以察覺，因此在診治過程中極易被忽略，為后期復發提供了機會，以及演變為病殘的主要因素[3-4]。本研究探究了舍曲林聯合利培酮治療精神分裂癥陰性癥狀的療效和安全性，現報道如下。

1 資料與方法

1.1 一般資料 在本院2014年5月-2016年5月收治的精神分裂癥患者中隨機選取116例進行臨床分析，按照隨機數字表法將其分為對照組和探討組，各58例。納入標準：（1）不存在嚴重軀體疾病和腦器質性疾病；……