169例早期鼻咽癌調(diào)強放療預后分析

[摘要] 目的 探討早期鼻咽癌患者調(diào)強放療的預后因素。 方法 回顧性分析了我院放療科共169例鼻咽癌患者的臨床資料并對其進行了分析。將放射治療應用到臨床診斷治療當中，旨在探討該方法的實際應用效果，為臨床研究和應用提供參考。 結(jié)果 本研究169例患者中鼻咽癌經(jīng)單純放射治療后4的生存率為85.7%，影響患者鼻咽癌放射治療生存率的預后因素主要包括：T分期、是否淋巴結(jié)轉(zhuǎn)移，而預后與化療與否似乎未見明顯相關(guān)。 結(jié)論 提示對于早期的鼻咽癌患者，預后相關(guān)因素為T分期、是否淋巴結(jié)轉(zhuǎn)移，而預后與化療與否似乎未見明顯相關(guān)。

[關(guān)鍵詞] 調(diào)強放射治療；鼻咽癌；臨床效果；術(shù)后預后

[中圖分類號] R739.6 [文獻標識碼] B [文章編號] 2095-0616（2013）13-181-02

Prognostic analysis of 169 cases of early nasopharyngeal carcinoma with intensity modulated radiation therapy

ZHENG Naiying SHAO Xunfan MO Zhiwen HUANG Zhong

Department of Radiotherapy， Guangzhou Medical University Cancer Institute and Hospital in Guangdong Province， Guangzhou 510095， China

[Abstract] Objective To explore the prognostic factors of early nasopharyngeal carcinoma patients with intensity modulated radiation therapy. Methods The clinical data of 169 patients with nasopharyngeal carcinoma in our hospital of radiotherapy department were analyzed retrospectively. This article applied radiation therapy into clinical diagnosis and treatment for exploring the practical application effect of this method and providing a reference for clinical study. Results In this study， the four-year survival rate of 169 cases with nasopharyngeal carcinoma after radiotherapy alone in them was 85.7%. The factors influencing the prognosis on survival rate of patients with nasopharyngeal carcinoma radiotherapy mainly included T-staging， lymph node metastasis or not， and there was no obvious correlation between prognosis and chemotherapy or not. Conclusion It suggested that the prognosis factors of patients with early nasopharyngeal carcinoma are T-staging and lymph node metastasis or not and there is no obvious correlation between prognosis and chemotherapy or not.

[Key words] Intensity modulated radiation therapy； Nasopharyngeal carcinoma； Clinical effect； Postoperative prognostic

鼻咽癌是指發(fā)生在鼻咽腔頂部以及側(cè)壁的一類惡性腫瘤，在我國耳鼻咽喉惡性腫瘤中發(fā)病率居于首位[1]。鼻咽癌患者中的男性約為女性的兩倍，發(fā)病年齡可以是各個年齡階段，但平均發(fā)病年齡在40歲左右。鼻咽癌有顯著的流行病學特點，主要的臨床癥狀包括：聽力下降，耳朵堵悶，頭痛以及鼻塞等。我國鼻咽癌的分布具有明顯的地域性特征，以廣東中部和廣西東部為主要發(fā)病地區(qū)并以此向周圍擴散[2]。因為鼻咽癌原發(fā)病灶的直徑較難測量，所以常常利用影像學資料顯示腫瘤浸潤的范圍并以此來計算容積[3]。本研究回顧性分析了我院放療科共169例鼻咽癌患者的臨床資料并對其進行了分析。將放射治療應用到臨床診斷治療當中，旨在探討該方法的實際應用效果，為臨床研究和應用提供參考，現(xiàn)報道如下。……