高鋁暴露癲癇患者前炎癥因子水平變化的臨床觀察

【摘要】 目的 探討高鋁暴露癲癇患者細胞因子水平變化及其與臨床發病的關系。

方法選取高鋁暴露區癲癇大發作患者12例，觀察其發作特征，檢測其血清鋁、血清腫瘤壞死因子α（TNFα）、白細胞介素6（IL6）、白細胞介素8（IL8）水平，并與13例非高鋁暴露區癲癇大發作患者和12例非高鋁暴露區健康體檢者比較。結果 高鋁暴露組的癲癇發作頻率、發作持續時間、合并新類型率均高于非高鋁暴露組（P＜0.05或0.01），高鋁暴露組腦電圖陽性率高于非高鋁暴露組，但差異無統計學意義（P＞0.05）。高鋁暴露組血鋁水平顯著高于非高鋁暴露組和正常對照組（P＜0.05或0.01），非高鋁暴露組血鋁水平高于正常對照組，但差異無統計學意義（P＞0.05）。高鋁暴露組血清TNFα、IL6、IL8水平高于非高鋁暴露組（P＜0.01），非高鋁暴露組又高于正常對照組（P＜0.05）。結論高鋁暴露癲癇患者具有血鋁水平高，癲癇臨床癥狀重，致炎因子水平高，御炎因子水平低等特點，高鋁暴露或血鋁增高的癲癇患者其臨床癥狀和細胞因子功能負面變化較血鋁正常者大，提示血鋁升高可能加重癲癇患者病情。

【關鍵詞】 癲癇；高鋁暴露；TNFα；IL6；IL8

文章編號：1003-1383(2010)06-0662-03 中圖分類號：R 742.1文獻標識碼：A

doi:10.3969/j.issn.1003-1383.2010.06.004

Clinical study of cell factor change in high alumina exposed epilepsy patients

WEI Shige，LI Tianzi，LI Xuebin，TANG Xionglin，LIANG Ye

（Clinical Academy ofYoujiang Medical College for Nationality，Baise Guangxi 533000）

【Abstract】 ObjectiveTo explore the cell factor change in high alumina exposed epilepsy patients and the relation with clinic occurrence.

Methods 12 patients with grand mal epilepsy who lived in high alumina area were chosen as high alumina exposed group， observed their clinical features and detected the blood alumina，serum tumor necrosis factorα（TNFα），interleukin6 (IL6) and interleukin8(IL8) level.So did 13 grand mal epilepsy patients(nonealumina exposed group) and 12 healthy person(control group) live in nonealumina exposed area，then compared the data among groups.

Results The seizure frequency， seizure duration and rate of combined new seizure type in the high alumina exposed group was higher than those in the nonealumina exposed group（P＜0.05 or 0.01）. There are no statistical significant difference between the high alumina exposed group and the nonealumina exposed group upon electroencephalogram(EEG)positive rate（P＞0.05）.Blood alumina level in the high alumina exposed group was higher than those in the nonealumina exposed group and control group（P＜0.05 or 0.01）.Blood alumina level of the nonealumina exposed group was higher than that of controlgroup，but there was no statistical significant difference between them（P＞0.05）.The blood TNFα、IL6、IL8 level in the alumina exposed group was higher than the nonealumina exposed group，and the blood TNFα、IL6、IL8 level in the nonealumina exposed groupwas higher than the control group（P＜0.01）.

Conclusion The blood alumina and cell factor level of the high alumina exposed epileptic patients` was high，and the epileptic clinical symptom was badly.High alumina exposed or increasing blood alumina level would bring more negative affect to epileptic patients than normal blood alumina level.That promoting epileptic patients` health would worsen if exposed to high alumina condition.

【Key words】epilepsy;high alumina exposed;TNFα、IL6、IL8

癲癇（Epilepsy）是由大腦神經元異常放電所引起的短暫中樞神經功能失常為特征的慢性腦部疾病，突然發生，反復發作是其特點，年發病率和患病率分別為0.5‰～0.7‰和5‰，是神經系統的常見疾病，本病雖然很少直接影響患者的生命，但因其療效欠佳，控制率低，病殘病死率高，給患者和社會帶來沉重的負擔［1］，本病的病因和病理機制目前還未完全明了，因此從發病機制著手研究探尋新的有效治療手段，仍是當今癲癇研究的重點課題。……