新生兒黃疸120例臨床分析

[摘要] 目的 探討口服思密達治療新生兒黃疸的臨床療效。方法 將我科2005年1月~2008年12月收治的120例新生兒黃疸的患兒隨機分為治療組和對照組各60例。治療組在酶誘導劑治療的基礎上加用思密達粉口服，3g×1/3包(1g)，用20mL溫水稀釋均勻口服，每日3次。對照組在酶誘導劑治療的基礎上加用藍光照射治療，每天照射8～12h。兩組均經皮黃疸儀測量正常(<12mg/L)后抽血查膽紅素。結果 兩組治療前血清膽紅素比較無顯著性差異(P>0.05)。每組治療前后比較差異顯著(P<0.01)，兩組治療后血清膽紅素值比較有差異(P<0.05)。兩組黃疸高峰日齡比較，治療組出現時間比對照組提前(P<0.05)。結論 思密達治療新生兒黃疸可以縮短黃疸持續時間，快速降低血清膽紅素，副作用少，臨床應用安全有效。

[關鍵詞] 新生兒黃疸;思密達;臨床分析

[中圖分類號] R722.17 [文獻標識碼] A [文章編號] 1673-9701(2010)04-53-02

Neonatal Jaundice:A Clinical Analysis of 120 Cases

CHEN LinglingQIU HuixianZHOU Shuming

Department of Pediatrics，Shenzhen Longgang District Central Hospital，Shenzhen 518116，China

[Abstract] Objective To observe the clinical efficacy of oral Smecta in the treatment of neonatal jaundice.Methods We divided 120 cases of neonatal jaundice in our hospital from Jan 2005 to Dec 2008 randomly into two groups;treatment group and control group with 60 cases for each group. The treatment group was given oral Smecta(3g×1/3 package(1g)，diluted with 20mL warm water，3 times a day) on the basis of the enzyme inducer treatment. The control group was given Blu-ray irradiation(a daily irradiation from 8 to 12h) on the basis of the enzyme inducer treatment.Jaundice was measured with transcutaneous jaundice meter and after jaundice was normal(<12mg/L)， the blood bilirubin was examined. Results The two groups showed no significant difference in the serum bilirubin before treatment(P>0.05)， each group showed a significant difference in the serum bilirubin before and after treatment(P<0.01)，and there was a significant difference in the serum bilirubin in the two groups after treatment(P<0.05). Jaundice peak day age of the treatment group appeared earlier than that of the control group(P<0.05). Conclusion Smecta for the treatment of neonatal jaundice can shorten the duration of jaundice and rapidly reduce serum bilirubin，and it is safe and effective，with less side effects.

[Key words] Neonatal jaundice;Smecta;Clinical analysis

新生兒黃疸是新生兒時期最常見的疾病，由新生兒的代謝特點或其他疾病引起，部分黃疸高但未結合膽紅素血癥可引起膽紅素腦病(核黃疽)，嚴重者死亡率高，存活者多留后遺癥[1]。因此，要求臨床醫生對每個患兒應盡快找出其原因，及時治療。我科應用思密達治療新生兒黃疸取得滿意療效，報道如下。

1資料與方法

1.1一般資料

將我科2005年1月~2008年12月收治的120例新生兒黃疸的患兒隨機分為治療組和對照組各60例。所有入選的患兒均為首診治療，病因為生理性黃疸、病理性黃疸或母乳性黃疸。就診時血清膽紅素水平在(150～310)μmol/L。其中生理性黃疸54例，病理性黃疸48例，母乳性黃疸18例，男68例，女52例，日齡:1.2～5.2d(平均4.1d)，胎齡平均(38.6±3.2)周，出生時體重平均(3210±468)g。……