[摘要] 目的 探討液基細(xì)胞學(xué)和陰道鏡檢查在診斷宮頸病變中的應(yīng)用價(jià)值。方法 選取698例患者,液基細(xì)胞學(xué)檢查TBS分類系統(tǒng)對宮頸病變的診斷,并在陰道鏡下取多點(diǎn)進(jìn)行病理學(xué)檢查。結(jié)果 液基細(xì)胞學(xué)檢查發(fā)現(xiàn)異常細(xì)胞698例,其中未明確診斷意義的不典型鱗狀細(xì)胞或腺細(xì)胞(ASCUS或AGCUS)38例,診斷為低度鱗狀上皮內(nèi)瘤變(LSIL)134例,高度鱗狀上皮內(nèi)瘤變(HSIL)40例,鱗癌105例,人乳頭狀瘤病毒(HPV)感染381例。結(jié)論 液基細(xì)胞學(xué)和陰道鏡檢查在診斷宮頸病變中有顯著的應(yīng)用價(jià)值。
[關(guān)鍵詞] 液基細(xì)胞學(xué);陰道鏡;宮頸病變;診斷;人乳頭狀瘤病毒(HPV)感染
[中圖分類號] R737.33 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1673-9701(2010)04-01-03
Liquid-based Cytology and Colposcopy in the Diagnosis of Cervical Lesions
HUANG XiaoxingHUANG ShiyongCHEN Yingyan
1. Department of Pathology,Yangjiang Municipal People’s Hospital,Yangjiang 529500,China;2. Department of Gynecology,the Yangjiang Municipal People’s Hospital,Yangjiang 529500,China
[Abstract] Objective To explore the diagnostic value of liquid based cytology test(LCT) combined with colposcopy in scanning cervical disease. Methods LCT and Besthesda system(TBS) were used in the diagnosis of 698 cases of cervial lesions and the pathological examination was performed under colposcopy by using multi-point biopsy. Results LCT revealed 698 cases of abnormal cells, in which 38 cases were atypical squamous cells or glandular cells of undetermined significance,134 cases of low-grade squamous intraepithelial neoplasia,40 cases of high-grade squamous intraepithelial neoplasia,105 cases of squamous carcinoma,and 381 cases of human papilloma virus infection. Conclusion Combination of liquid-based cytology and colposcopy is of great value in scanning cervical lesions.
[Key words] Liquid based cytology;Colposcopy;Cervical disease;Diagnosis;Human papilloma virus infection
常規(guī)巴氏宮頸涂片一直被應(yīng)用于宮頸癌的普查,它是一種傳統(tǒng)的診斷方法,雖然它己被認(rèn)為是一種標(biāo)準(zhǔn)方法,但是在美國與此相關(guān)的一系列訴訟案暴露了其應(yīng)用中的缺陷[1]。樣本采集是最基本的一個(gè)步驟,非最佳采樣是導(dǎo)致假陽性率高的主要原因,以液化為基礎(chǔ)的宮頸細(xì)胞學(xué)技術(shù)可以克服在宮頸癌普查中遇到的一些問題,筆者總結(jié)本組資料,報(bào)道如下。
1資料與方法
1.1一般資料
本組資料選自我院2006年4月~2009年4月行液基細(xì)胞學(xué)檢查患者1546例,其中698例患者因細(xì)胞學(xué)異常、重度糜爛或可疑癌行陰道鏡檢查和鏡下定位活檢。年齡15~72歲,平均年齡(24.8±12.5)歲,孕次0~4次,產(chǎn)次0~2次,均有不同程度的性經(jīng)驗(yàn),符合陰道鏡檢查指征。陰道鏡檢查前均已行TCT檢查,陰道鏡由專職醫(yī)生進(jìn)行操作。
1.2方法
1.2.1標(biāo)本采集受檢前24h內(nèi)無陰道檢查及性交……