胃食管反流病給予不同療程奧美拉唑治療的對比分析

蘇德云

[摘要] 目的 分析胃食管反流病給予不同療程奧美拉唑治療的對比。方法 方便選取2017年3月—2018年9月該院收治的胃食管反流患者87例，所有患者均采用奧美拉唑治療，隨機單雙數法分為對照組43例治療4周、觀察組44例治療6周，對比兩組患者臨床療效以及安全性和效率。結果 觀察組患者臨床總有效率97.73%（43/44）顯著高于對照組83.72%（36/43），差異有統計學意義（χ2=5.109，P<0.05）;觀察組患者治療時并發癥率9.30%、對照組4.55%，差異無統計學意義（χ2=0.766，P>0.05）;治療前觀察組患者癥狀積分（2.62±0.31）分和對照組（2.52±0.26）分比無較大差異，且差異無統計學意義（t=1.632，P>0.05）;治療后發現觀察組反酸、燒心等癥狀積分（1.01±0.17）分和對照組比（1.42±0.24）分更少，差異有統計學意義（t=9.212，P<0.05）;胃鏡檢查下治療前效果較差，數據無統計學意義（t=1.846，P>0.05）;觀察組治療后胃鏡檢查狀況（0.96±0.08）分低于對照組（1.37±0.18）分，差異有統計學意義（t=13.782，P<0.05）。結論 胃食管反流采用奧美拉唑治療6周后，患者臨床療效更高，不良反應少、癥狀計分和胃鏡檢查均更優。

[關鍵詞] 胃食管反流病;奧美拉唑;療程;癥狀積分;黏膜發紅

[中圖分類號] R571? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-0742（2019）05（c）-0131-03

[Abstract] Objective To analyze the comparison of different courses of omeprazole in the treatment of gastroesophageal reflux disease. Methods Convenient select from March 2017 to September 2018， 87 patients with gastroesophageal reflux disease were treated in our hospital. All patients were treated with omeprazole. The patients were randomly divided into the control group and 43 patients for 4 weeks. The observation group of 44 patients were treated for 6 weeks， and the clinical efficacy， safety and efficiency of the two groups were compared. Results The total clinical effective rate of the observation group was 97.73% （43/44）， which was significantly higher than that of the control group 83.72%， （36/43）. The difference was statistically significant （χ2=5.109， P<0.05）. The rate was 9.30% and the control group was 4.55%. The difference was not statistically significant （χ2=0.766， P>0.05）. There was no significant difference between the symptom score （2.62±0.31）points and the control group （2.52±0.26）points in the observation group before treatment. The difference was not statistically significant （t=1.632， P>0.05）. After treatment， the symptom scores of acid reflux and heartburn （1.01±0.17）points and control group （1.42±0.24）points were less. The difference was statistically significant（t=9.212， P<0.05）; the effect before gastroscopy was poor， the data were not statistically significant （t=1.846， P>0.05）; the observation group was less than （0.96±0.08）points after treatment. The control group （1.37±0.18）points was statistically significant （t=13.782， P<0.05）. Conclusion Gastroesophageal reflux after 6 weeks of treatment with omeprazole has higher clinical efficacy， less adverse reactions， better symptom scores and gastroscopy.