血液透析對老年慢性腎功能衰竭患者炎癥標志物的影響研究

青琴+艾衣坦·阿依特哈孜

[摘要] 目的 探討血液透析對老年慢性腎功能衰竭患者炎癥標志物的影響。 方法 方便選取2014年10月—2016年1月于博州人民醫院腎內科進行血液透析的老年慢性腎功能衰竭患者82例為觀察組，同時選取100名于該院體檢的健康老年人為對照組，所選取的兩組對象年齡均為60～75歲。分別于入院時、14 d、30 d、60 d后檢測透析前后血清脂聯素、CRP、IL-6等炎癥標志物的水平，將兩組炎癥標志物水平進行對比。 結果 觀察組患者血清脂聯素、CRP、IL-6分別為（14.88±2.56）mg/L、（7.35±1.88）mg/L、（60.33±6.77）pg/L，對照組患者血清脂聯素、CRP、IL-6分別為（7.10±0.89）mg/L、（2.11±0.25）mg/L、（43.25±5.20）pg/L，觀察組患者血清脂聯素、CRP、IL-6顯著高于對照組，差異有統計學意義（P<0.05）；觀察組患者炎癥標志物血清脂聯素、CRP、IL-6的水平隨著時間的延長不斷升高，但各時間點透析前后水平差異無統計學意義（P>0.05）；4個時刻點血液透析前炎癥標志物水平相比，2個月后比其他3個時刻點顯著升高，差異有統計學意義（P<0.05）。結論 血液透析不能降低老年慢性腎功能衰竭患者炎癥標志物血清脂聯素、CRP、IL-6的水平，因此有必要在臨床治療中進行抗炎治療。

[關鍵詞] 血液透析；老年；慢性腎功能衰竭；炎癥標志物

[中圖分類號] R692.5 [文獻標識碼] A [文章編號] 1674-0742（2017）01（a）-0035-03

[Abstract] Objective To investigate the effect of hemodialysis on inflammatory markers in elderly patients with chronic renal failure. Methods Convenient selection from October 2014 to January 2016 in the Department of Nephrology dialysis Bozhou people's Hospital of elderly patients with chronic renal failure and 82 cases of the observation group， and selected 100 healthy elderly patients in our hospital as the control group， the two groups of age were selected are 60～75 years old. The levels of serum adiponectin， CRP， IL-6 and other inflammatory markers were compared between the 30 groups at admission， 14 days， days and 60 days respectively， and the levels of inflammatory markers were compared between the two groups. Results The levels of serum adiponectin， CRP and IL-6 in the observation group were （14.88 ± 2.56） mg/L， （7.35 ± 1.88） mg/L， （60.33 ± 6.77） pg/L， the levels of serum adiponectin， CRP and IL-6 in the control group were（7.10 ± 0.89） mg/L， （2.11 ± 0.25） mg/L， （43.25 ± 5.20） pg/L， in the observation group， serum adiponectin， CRP and IL-6 were significantly higher than that of the control group ，the difference was statistically significant（P<0.05）； the observation group of patients with inflammatory markers， serum adiponectin， CRP， IL-6 levels increased with the prolonging of time， but there was no significant difference between before and after each time point of dialysis levels， there was no statistically significant（P>0.05）； the 4 time points of hemodialysis preinflammatory marker levels compared to 2 months later than the other three time points were significantly increased ，the difference was statistically significant（P<0.05）. Conclusion Hemodialysis can not reduce the level of serum adiponectin， CRP and IL-6 in elderly patients with chronic renal failure， so it is necessary to carry out anti-inflammatory treatment in clinical treatment.