葛根芩連湯加減對頸動脈粥樣硬化斑塊的臨床研究

王佩軍+艾悅海+魏永傳+張學慶

【摘要】 目的：觀察葛根芩連湯加減治療頸動脈粥樣硬化斑塊的療效。方法：選取2010-2012年在本院就診的48例頸動脈粥樣斑塊患者，按照隨機數字表法將其分為治療組和對照組各24例，治療組給予葛根芩連湯加減治療，對照組給予口服辛伐他汀治療，觀察比較兩組患者治療前與治療6個月后頸動脈IMT、course積分、血脂情況、CRP及頸動脈中醫證候積分。結果：與治療前比較，兩組治療6個月后的頸動脈IMT、crouse積分、TC、TG、LDL、CRP及中醫證候積分均明顯降低（P<0.05），HDL明顯升高（P<0.05），且治療組的crouse積分、CRP及中醫證候積分均明顯低于對照組（P<0.01），而兩組上述其余指標均無明顯差異（P>0.05）。結論：葛根芩連湯具有良好的抗動脈粥樣硬化作用，值得臨床推廣。

【關鍵詞】 頸動脈粥樣硬化； 中醫藥療法； 頸動脈內膜中層厚度； 葛根芩連湯

The Clinical Research of Gegen Qinlian Decoction on Carotid Artery Atherosclerosis/WANG Pei-jun，AI Yue-hai，WEI Yong-chuan，et al.//Medical Innovation of China，2014，11（28）：019-021

【Abstract】 Objective：To observe the effect of Gegen qinlian decoction in treatment of carotid artery atherosclerosis.Method：Forty-eight patients with carotid artery atheromatous plaque in our hospital from 2010 to 2012 were selected，they were divided into the treatment group and the control group according to the random number table method，24 cases in each group.The treatment group was given Gegen qinlian decoction and the control group wan given Simvastatin.The carotid artery intima-medial thickness，crouse plaque integral，serum lipids，CRP and TCM Syndromes of carotid artery of the two groups before and after 6 months of treatment were observed and compared.Result：Compared with before treatment，the carotid artery intima-medial thickness，crouse plaque integral，TC，TG，LDL，CRP and TCM Syndromes of carotid artery after 6 months of treatment were significantly lower than before treatment（P<0.05），HDL was significantly higher than before treatment（P<0.05），and crouse plaque integral，CRP and TCM Syndromes of carotid artery in treatment group were significantly lower than those in control group（P<0.01）.And there were no significant differences in the remainder of the index between the two groups（P>0.05）.Conclusion：Gegen qinlian decoction has a good anti-atherosclerosis effect，is worthy of clinical promotion.

【Key words】 Carotid artery atherosclerosis； Traditional Chinese Medical therapy； Carotid artery intima-medial thickness （IMT）； Gegen qinlian decoction

First-authors address：Weifang NO.2 Peoples Hospital，Weifang 261041，China

doi：10.3969/j.issn.1674-4985.2014.28.007

動脈粥樣硬化及其不穩定斑塊是引起心腦血管急癥的重要危險因素。頸動脈是最易受累的大血管之一，頸動脈粥樣硬化即指雙側頸總動脈、頸總動脈分叉處及頸內、外動脈顱外段血管壁僵硬，內膜下脂質沉積、斑塊形成及管腔狹窄[1]。頸動脈粥樣硬化程度與缺血性腦卒中的發生密切相關[2]。對其進行早期干預可減輕或逆轉動脈粥樣硬化，減少心腦血管病的發生率。作者采用葛根芩連湯加減治療頸動脈粥樣硬化24例，取得了一定的效果。

1 資料與方法

1.1 一般資料 選取2010-2012年在本院就診均經頸動脈超聲檢查確診存在頸動脈粥樣硬化斑塊的48例患者，按照隨機數字表法將其分為對照組和治療組各24例。對照組24例患者中，男15例，女9例；年齡54～78歲，平均（62±4.6）歲；其中高血壓13例，糖尿病5例，高血脂16例，冠心病5例；……