

摘要 潰瘍性結腸炎是以黏膜炎癥復發和緩解交替為特征的疾病,其診斷和療效評估均需要綜合臨床表現、實驗室檢查、內鏡檢查、組織病理學表現進行綜合判斷,因此通過量表評估具有重要作用。伴隨潰瘍性結腸炎治療目標從臨床緩解、黏膜愈合到組織學緩解的發展,評估量表也在不斷進步。本文從臨床評估、內鏡評估、組織學評估、患者報告評估等多角度對目前常用的量表作一綜述,旨在幫助臨床工作者更全面地了解不同量表的優劣,選擇更適合的評估方法。
關鍵詞 結腸炎,潰瘍性; 臨床評估量表; 內鏡評估量表; 組織學評估量表
Progress of Research on Ulcerative Colitis Evaluation Scale LU Xingyao,HU Hongyi. Department of Spleen and Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai (200032)
Correspondence to: HU Hongyi, Email: hongyihu2003@shutcm.edu.cn
Abstract Ulcerative colitis is characterized by the alternation of recurrence and remission of mucosal inflammation. Both its diagnosis and efficacy evaluation require the combination of clinical, laboratory examination, endoscopy, and histology. Therefore, evaluation scales are important for ulcerative colitis. Many different scales have been developed to accompany the escalation of therapeutic goals from clinical remission and mucosal healing to histological remission. This article summarized the current commonly used scales from multiple perspectives, including clinical evaluation, endoscopic evaluation, histological evaluation, and patient?reported assessment, which aimed to help clinical practitioners understand the advantages and disadvantages of different scales more comprehensively and choose more appropriate assessment method.
Key words Colitis, Ulcerative; Clinical Evaluation Scale; Endoscopic Evaluation Scale; Histological Evaluation Scale
潰瘍性結腸炎(ulcerative colitis, UC)是一種以結直腸黏膜和黏膜下層炎癥和潰瘍形成為主要特點的疾病,以病程復發和緩解交替為特征,腹痛、腹瀉、黏液膿血便為其主要臨床表現[1?2]。UC的確診及其活動程度和療效的評估均需綜合患者的臨床表現、實驗室檢查、內鏡檢查和組織病理學表現作出判斷[1,3]。目前治療UC的目標包括患者臨床癥狀、血清學和糞便標志物、患者報告結局(patient?reported outcome, PRO)和內鏡表現的改善[4]??茖W、有效、可靠的量表有助于準確評估UC嚴重程度,評價療效和預測疾病復發。結合UC臨床緩解、內鏡緩解和組織學緩解的三級目標[1],本文擬從臨床評估、內鏡評估、組織學評估和患者自我評估這4個角度對目前常用的量表進行總結。
一、臨床評估量表
臨床評估量表可以評估患者整體情況,一般包含癥狀、實驗室指標、內鏡指標、醫師評估等多方面?!?br>