陰道微生態(tài)變化與宮頸病變的相關(guān)性研究

劉蔚

【摘要】 目的：分析陰道微生態(tài)變化與宮頸病變的相關(guān)性。方法：選取本院2015年7月-2017年7月于本院行體檢的婦女300例為研究對(duì)象，根據(jù)陰道脫落細(xì)胞學(xué)TCT檢查結(jié)果分為NILM組、ASC組、LSIL組、HSIL組和SCC組共五組，所有患者均行陰道微生態(tài)系統(tǒng)檢測(cè)，比較各組間陰道分泌物病原體檢出情況和陰道環(huán)境。結(jié)果：SCC組患者BV、念珠菌陽(yáng)性檢出率均高于NILM組、ASC組和LSIL組，比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05），與HSIL組比較差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。NILM組與ASC組、LSIL組以及HSIL組BV、念珠菌、滴蟲(chóng)陽(yáng)性檢出率比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。ASC組和LSIL組的滴蟲(chóng)陽(yáng)性檢出率明顯高于其他三組，比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。SCC組和HSIL組清潔度Ⅲ～Ⅳ級(jí)比例明顯高于其他三組，比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。LSIL組、HSIL組和SCC組菌群多樣性異常比例均明顯高于NILM組，比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。ASC組、LSIL組、HSIL組和SCC組pH值>4.5比例均明顯高于NILM組，比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：陰道微生態(tài)環(huán)境的失調(diào)，可相應(yīng)增加宮頸病變的發(fā)病率，臨床應(yīng)積極防治生殖道感染性疾病，及時(shí)調(diào)節(jié)和糾正陰道微環(huán)境，早期預(yù)防宮頸癌的發(fā)病。

【關(guān)鍵詞】 陰道微生態(tài); 宮頸病變; 相關(guān)性

【Abstract】 Objective：To analyze the correlation between vaginal microflora and cervical lesions.Method：300 women in our hospital from July 2015 to July 2017 were selected as the subjects.According to the results of TCT，five groups were divided into NILM group，ASC group，LSIL group，HSIL group and SCC group.All the patients were detected by vaginal microecology system，and the conditions of the vaginal secreting pathogens were compared and the vaginal environment was compared between each group.Result：The positive rate of BV and Candida albicans in SCC group were higher than those of NILM group，ASC group and LSIL group（P<0.05），and there was no significant difference between HSIL group and HSIL group（P>0.05）.There were significant difference between the NILM group and ASC group，LSIL group and HSIL group，Candida and Trichomonas（P<0.05）.The positive rates of Trichomonas in ASC group and LSIL group were significantly higher than those in the other three groups（P<0.05）.The ratios of degree Ⅲ to Ⅳ were significantly higher than those of the other three groups（P<0.05）.The ratio of abnormal diversity in LSIL group，HSIL group and SCC group were significantly higher than that in NILM group（P<0.05）.The percentage of pH>4.5 in ASC group，LSIL group，HSIL group and SCC group were significantly higher than that in NILM group（P<0.05）.Conclusion：The maladjustment of the vaginal microecological environment can increase the incidence of cervical lesions，should actively prevent and cure the infectious diseases of the genital tract，adjust and correct the vaginal microenvironment in time，and prevent the incidence of cervical cancer in the early stage.

【Key words】 Vaginal microecology; Cervical lesions; Correlation

First-authors address：Jiangxi Province Maternal and Child Health Hospital，Nanchang 330006，China