艾司西酞普蘭治療伴抑郁酒精依賴的效果及其對患者生活質量的影響

阿拉木斯

[關鍵詞] 艾司西酞普蘭;抑郁;酒精依賴;生活質量

[中圖分類號] R749.41? ? ? ? ? [文獻標識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）20-0101-03

Effect of escitalopram in treatment of alcohol dependence with depression and its effect on quality of life of patients

A Lamusi

Addiction Medicine Center，Inner Mongolia Mental Health Center， Huhehot? ? 010010， China

[Abstract] Objective To explore and analyze the effect of escitalopram in treatment of alcohol dependence with depression and its effect on quality of life of patients. Methods Research subjects were selected from January 2019 to April 2020， and all the 72 patients with depression and alcohol dependence were admitted to our hospital for treatment. According to the random number table， 36 patients in the conventional group were treated with conventional alcohol detoxication therapy， and 36 patients in the study group were treated with escitalopram in addition to the conventional group. The changes of depression mood， sleep quality， alcohol dependence and social dysfunction， quality of life and the rates of adverse reactions were statistically analyzed between the routine group and the study group. Results After treatment， the HAMD score， PQI score， alcohol dependence score and social function deficit score in the study group were lower than those in the control group， and the GQOL-74 scores in mental health， material life， physical health and social function were higher than those in the control group， and the differences were statistically significant（P<0.05）. No significant difference was observed in the total rate of adverse reaction rate between the conventional group and the study group（P>0.05）. Conclusion Escitalopram can effectively relieve depression， improve sleep quality， reduce alcohol dependence， improve social function of patients， and effectively improve the quality of life of patients with high drug safety， which is worthy of promotion.

[Key words] Escitalopram; Depression; Alcohol dependence; Quality of life

酒精依賴的出現通常與患者長期飲酒有關，飲酒過量、持續飲酒時間過長會使得患者難以控制飲酒行為，無法對自身行為進行約束，并最終致使酒精依賴發生[1-2]。酒精依賴癥狀不僅會對患者生理功能產生負面影響，還會在患者心理層面構成情緒干擾，患者容易因此出現焦慮、煩躁情緒[3-4]。據相關研究統計結果數據顯示，酒精依賴患者更容易出現精神障礙癥狀，其發生率為正常人群的2～4倍，其中同時伴發抑郁癥狀的酒精依賴患者群體的總占比大約為10%[5-6]。抑郁情緒的出現會導致酒精依賴患者睡眠質量降低，對患者的戒酒效果產生嚴重負面影響[7]。本研究旨在探討分析艾司西酞普蘭治療伴抑郁酒精依賴的效果及對患者生活質量的影響，現報道如下。

1 資料與方法

1.1一般資料

選取2019年1月至2020年4月于我院就診治療的72例伴抑郁酒精依賴患者。納入標準：患者病情符合伴抑郁酒精依賴診斷標準[8]。排除標準[9]：認知異常者、溝通困難者、對研究藥物過敏者。采用隨機數字表法分為兩組，每組各36例。常規組患者采用常規酒精脫依賴治療，研究組患者在常規組基礎上應用艾司西酞普蘭治療。其中所有患者均為男性，常規組年齡25～53歲，平均（33.69±6.38）歲，飲酒時間6～18年，平均（10.47±3.14）年。研究組年齡26～54歲，平均（34.13±6.17）歲，飲酒時間6～18年，平均（10.56±3.22）年。兩組患者臨床資料比較，差異無統計學意義（P>0.05），具有可比性。該研究經醫院醫學倫理標準委員會批準，所有研究對象均知情且同意參與。