阿卡波糖片對老年急性心肌梗死患者心室重構的影響

柳蔭

【摘要】 目的：分析阿卡波糖片對老年急性心肌梗死患者心室重構的影響。方法：選取2014年

10月-2016年10月本院收治的老年急性心肌梗死疾病患者92例作為研究對象，按照隨機數字法分為對照組和治療組，每組各46例。對照組采用常規抗心肌梗死用藥方案，治療組在對照組基礎上加用阿卡波糖片。比較用藥前后左心室射血分數、梗死面積、心房鈉尿肽、TNF-α等相關指標水平的改善幅度、老年急性心肌梗死藥物治療總有效率、用藥期間出現的心室重構例數、心肌功能恢復正常時間和用藥總時間、藥物不良反應率。結果：治療組在用藥前后左心室射血分數、梗死面積、心房鈉尿肽、TNF-α等相關指標水平的改善幅度均顯著高于對照組，比較差異均有統計學意義（P<0.05）；治療組老年急性心肌梗死藥物治療總有效率為91.3%，高于對照組的71.7%，比較差異有統計學意義（P<0.05）；用藥期間，治療組心室重構出現3例，少于對照組的11例，比較差異有統計學意義（P<0.05）；心肌功能恢復正常時間和用藥總時間均少于對照組，比較差異均有統計學意義（P<0.05）；治療組藥物不良反應率為4.3%，顯著低于對照組的21.7%，比較差異有統計學意義（P<0.05）。結論：老年急性心肌梗死疾病患者采用阿卡波糖片進行治療，可以有效控制心室重構現象的發生，大幅度改善心肌功能，縮短用藥時間。

【關鍵詞】 老年； 急性心肌梗死； 阿卡波糖片； 心室重構； 效果

【Abstract】 Objective：To analyze the Acarbose Tablet effect on ventricular remodeling in elderly patients with acute myocardial infarction patients disease with the clinical effect of treatment for Acarbose Tablet.Method：From October 2014 to October 2016 in our hospital，92 elderly patients with acute myocardial infarction in our hospital were selected as research objects，they were divided into control group and treatment group according to the random number table method，46 cases in each group.The control group was treated with conventional anti myocardial infarction therapy，the treatment group was given Acarbose Tablet based on the control group.The left ventricular ejection fraction，infarct size，atrial natriuretic peptide，TNF-α and other related indicators of the levels improvement，the elderly patients with acute myocardial infarction treatment，the total efficiency of treatment during ventricular remodeling cases，myocardial function recovery time and total treatment time，adverse drug reaction rate of two groups were compared before and after treatment.Result：The patients in the treatment group before and after treatment，left ventricular ejection fraction，infarct size，atrial natriuretic peptide，TNF-α and other related indicators of the levels improvement were better than these of the control group，the differences were statistically significant（P<0.05）；the total effective rate of the treatment group was 91.3%，higher than that of control group 71.7%，the difference was statistically significant（P<0.05）；during the period of medication，there were 3 cases of ventricular remodeling in the treatment group，less than 11 cases in the control group，the difference was statistically significant（P<0.05）；myocardial function recovery time and the total treatment time was shorter than tthat of he control group，the difference was significant（P<0.05）；the adverse drug reaction rate was only 4.3%，lower than 21.7% in the control group，the difference was statistically significant（P<0.05）.Conclusion：Elderly patients with acute myocardial infarction disease were treated by Acarbose Tablet，can effectively control the occurrence of ventricular remodeling，improve cardiac function，shorten the treatment time.endprint

【Key words】 Elderly； Acute myocardial infarction； Acarbose tablet； Ventricular remodeling； Effect

First-authors address：Puer Peoples Hospital，Puer 665000，China

doi：10.3969/j.issn.1674-4985.2017.25.012

臨床上遇到的大多數急性心肌梗死疾病患者都會同時存在糖耐量水平降低的問題，對心室重構現象的產生可以產生非常重要的影響，對廣大患者特別是老年患者的正常生活造成嚴重的不良影響[1-3]。阿卡波糖屬于臨床上近年來應用較為廣泛的α-糖苷酶抑制藥的一種類型，該藥物能夠使人體的腸道對碳水化合物質的吸收過程得到有效的緩解，同時可以控制餐后血糖水平，調節血脂，減輕炎癥反應程度，使急性心肌梗死帶來的危害明顯降低[4-6]。本文主要分析老年急性心肌梗死疾病患者采用阿卡波糖片進行治療的臨床效果，現報道如下。……