吳龍兵
【摘要】 目的 探討計算機斷層掃描(CT)小腸造影評估Crohns病活動度的臨床價值。方法 42例活動期Crohns病患者作為觀察組, 33例緩解期Crohns病患者作為對照組。所有患者均接受CT小腸造影檢查, 對比檢查結果。結果 兩組患者的病變強化方式比較, 差異有統計學意義(P<0.05)。觀察組腸腔狹窄或梗阻例數多于對照組, 游離緣假性憩室例數少于對照組, 差異均具有統計學意義(P<0.05)。觀察組腸系膜密度增高、腹腔淋巴結腫大、梳狀征、蜂窩織炎例數均多于對照組, 差異均具有統計學意義 (P<0.05)。觀察組腸壁厚度為(10.6±2.5)mm, 厚于對照組的(4.9±2.0)mm, 觀察組病變腸壁動脈期CT值為(97.1±13.5)Hu、病變腸壁門脈期CT值為(109.8±14.6)Hu, 均高于對照組的(74.2±6.4)、(81.6±5.7)Hu, 差異均具有統計學意義 (P<0.05)。結論 CT小腸造影可以準確地鑒別Crohn's病活動期與緩解期, 在評估Crohns病活動度方面有重要的臨床實用價值。
【關鍵詞】 計算機斷層掃描;小腸造影;Crohns病
DOI:10.14163/j.cnki.11-5547/r.2017.29.014
【Abstract】 Objective To investigate the clinical value of computer tomography (CT) small bowel radiography in evaluating activity of Crohns disease. Methods There were 42 patients with active stage Crohns disease as observation group, and 33 patients with remission stage of Crohns disease as control group. All patients received CT small bowel radiography examination, and their examination results was compared. Results Both groups had statistically significant difference in lesion enhancement mode (P<0.05). The observation group had more intestinal stenosis or obstruction cases than the control group, and less free fake diverticulum cases than the control group. Their difference was statistically significant (P<0.05). The observation group had more cases of increased mesenteric density, abdominal lymph nodes, comb symptoms and cellulitis than the control group, and their difference was statistically significant (P<0.05). The observation group had thicker intestinal wall thickness as (10.6±2.5) mm than (4.9±2.0) mm in the control group. The observation group had CT value of arterial phase as (97.1±13.5) Hu and CT value of portal period as (109.8±14.6) Hu, which were all higher than (74.2±6.4) and (81.6±5.7) Hu in the control group, and their difference was statistically significant (P<0.05). Conclusion CT small bowel radiography can accurately identify the active and remission stage of Crohns disease, and has important clinical practical value in evaluating the activity of Crohns disease.
【Key words】 Computer tomography; Small bowel radiography; Crohns disease
Crohns病是目前臨床上常見的一種慢性反復發作的腸道炎癥性疾病, 其病情常處于活動期遷移至緩解期, 然后又復發至活動期的循環[1]。值得注意的是, Crohns病的治療方案與其疾病活動度密切相關, 即疾病活動度不同, 其治療方案亦隨之發生改變, 在此背景下, 正確判斷Crohns病的疾病活動度即具有重要的臨床意義[2]。本研究旨在探討CT小腸造影評估Crohns病活動度的臨床價值, 現報告如下。
1 資料與方法
1. 1 一般資料 選取2011年1月~2016年12月本院收治的42例活動期Crohns病患者作為觀察組, 33例緩解期Crohns病患者作為對照組。簡化Crohns病活動指數(CDAI)評分>4分判斷為活動期, ≤4分判斷為緩解期。其中, 觀察組男26例, 女16例;平均年齡(32.8±11.9)歲;對照組男19例, 女14例;平均年齡(32.0±11.5)歲。兩組患者性別、年齡比較, 差異無統計學意義(P>0.05), 具有可比性。endprint
1. 2 方法 所有患者均接受CT小腸造影檢查, 步驟包括如下幾個方面:①術前準備:檢查前1 d晚餐后禁食, 并且在晚餐后30 min左右口服硫酸鎂以及足量的水清潔腸道, 檢查當日早餐禁食, 檢查前在醫護人員指導下20~25 min內口服1000~1500 ml的2.5%等滲甘露醇溶液, 休息10 min后, 再在20~25 min內口服500~1000 ml的2.5%等滲甘露醇溶液。在CT掃描前10 min內肌內注射山莨菪堿0.2 mg/kg。②小腸CT造影檢查:給予患者仰臥位, 先給予腹部常規CT平掃, 掃描參數包括層厚5 mm、層間距 5 mm, 掃描范圍從膈頂緣直至恥骨聯合下緣。常規……