藍芩口服液治療慢性咽炎隨機對照試驗的系統評價和Meta分析

李娜+楊豐文+陸中英+張冬+劉春香+鄭文科

[摘要] 系統評價藍芩口服液治療慢性咽炎的療效和安全性。計算機檢索PubMed，Embase，Cochrane Library，CBM，CNKI，VIP，萬方科技數據庫，收集藍芩口服液治療慢性咽炎的隨機對照研究，檢索時限均為從建庫至2017年3月，由2名研究者按照納入和排除標準獨立進行文獻篩選、資料提取，用Cochrane偏倚評估手冊進行質量評價并交叉核對。采用RveMan.5.3軟件進行數據分析。共納入13個隨機對照試驗，共計1 642例慢性咽炎患者。Meta分析結果顯示： ①有效率：藍芩口服液治療組優于對照組（常規治療或其他藥物治療）；②IL-2：藍芩口服液治療組優于對照組（MD及95% CI，2.20[1.91，2.48]，P<0.000 01）；③TNF-α：藍芩口服液治療組優于對照組（MD及95%CI，0.75[0.60，0.90]，P<0.000 01）；④不良反應：無安全性信息報告。基于現有臨床證據，藍芩口服液治療慢性咽炎的有效率優于常規治療或其他藥物治療。但由于納入研究的方法學質量普遍較低，需要嚴格方法學設計和質量控制的臨床研究提供高質量的證據。

[關鍵詞] 藍芩口服液；慢性咽炎；隨機對照試驗；系統評價；Meta分析

Lanqin oral liquid for the treatment of chronic pharyngitis：

systematic review and Meta-analysis of randomized clinical trials

LI Na1，YANG Feng-wen1，LU Zhong-ying1，ZHANG Dong2，LIU Chun-xiang2，ZHENG Wen-ke2

（1. Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China；

2. Center for Evidence-Based Medicine，Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China）

[Abstract] To systematically assess the effectiveness and safety of lanqin oral liquid for the treatment of chronic pharyngitis. Databases including PubMed，Embase，The Cochrane Library，SinoMed，CNKI，VIP and Wanfang Data were electronically searched in March 2017 for randomized controlled trials（RCTs） on Lanqin oral liquid for the treatment of chronic pharyngitis. Two authors independently screened literature，extracted data，and assessed the risk of bias of included studies. Then，meta-analysis was performed by RevMan 5.3 software. Thirteen RCTs were included with a total of 1 642 patients. The results of meta-analysis showed that the efficiency of lanqin oral liquid were significantly higher than those of conventional therapy or other treatments；Besides，lanqin oral liquid could significantly increase the amount of IL-2 further more，lanqin oral liquid could significantly reduce the amount of TNF-α. Safety of lanqin oral liquid was not concerned by any RCT. Current evidence indicates that the efficiency of lanqin oral liquid was better than conventional therapy or other treatments. Due to the poor quality of the included studies，the above conclusion should be verified by more RCTs of high quality.

[Key words] Lanqin oral liquid；chronic pharyngitis；randomized controlled trial；dystematic review；Meta-analysis

慢性咽炎是指咽喉部黏膜的慢性炎癥，是臨床上常見病癥，具有病程長、反復發作等特點，主要是因細菌、病毒等因素長期刺激所致，多發于成年人[1]。慢性咽炎患者的臨床表現主要有咽部疼痛、有異物感、發癢及咳嗽等，尤其是在晨起刷牙時會出現反射性的惡心、欲吐等現象，影響患者及其家屬的生活質量[1]。目前藍芩口服液治療慢性咽炎的臨床研究較多，但缺乏系統的分析和評價。本研究旨在對藍芩口服液治療慢性咽炎的臨床效果進行系統評價，以期為藍芩口服液在臨床的正確應用提供依據。