曲伏前列素滴眼液治療原發性開角型青光眼和高眼壓癥

朱海平，鄧德勇，謝美娜

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·臨床報告·

曲伏前列素滴眼液治療原發性開角型青光眼和高眼壓癥

朱海平，鄧德勇，謝美娜

?METHODS: Eighty cases (eighty eyes) of patients with primary open-angle glaucoma and ocular hypertension in our hospital from Mar.2013 to Mar.2016 were randomly selected. These patients were divided into two groups according to the treatment methods, namely travoprost drops solution group (n=40) and latanoprost eye drops group (n=40), the clinical efficacy, visual acuity, astigmatism, intraocular pressure and adverse events of the two groups were analyzed.

?RESULTS: The total treatment efficiency of the travoprost drops solution group 95% (38/40) was significantly higher than the latanoprost eye drops group 80% (32/40) (P<0.05). The eyesight was significantly higher (P<0.05), the astigmatism, intraocular pressure was significantly lower (P<0.05). The incidence of adverse reactions 25% (10/40) was significantly lower than the latanoprost eye drops group 53% (21/40) (P<0.05).

?CONCLUSION: Travoprost drops solution in the treatment of primary open-angle glaucoma and ocular hypertension has better ocular hypotensive effect and higher safety than latanoprost eye drops.

目的:研究曲伏前列素滴眼液治療原發性開角型青光眼和高眼壓癥的降眼壓效果及安全性。

方法:隨機選取2013-03/2016-03我院收治的原發性開角型青光眼和高眼壓癥患者80例80眼，依據不同治療方法分為兩組：曲伏前列素滴眼液組(n=40)和拉坦前列素滴眼液組(n=40)，對兩組患者的臨床療效、視力、散光度、眼壓及不良反應發生情況進行統計分析。

結果:曲伏前列素滴眼液組患者治療的總有效率95%(38/40)顯著高于拉坦前列素滴眼液組80%(32/40)，差異有統計學意義(P<0.05)。曲伏前列素滴眼液組患者治療后視力顯著高于拉坦前列素滴眼液組，差異有統計學意義(P<0.05)，散光度、眼壓均顯著低于拉坦前列素滴眼液組，差異有統計學意義(P<0.05)，不良反應發生率25%(10/40)顯著低于拉坦前列素滴眼液組53%(21/40)，差異有統計學意義(P<0.05)。

結論：曲伏前列素滴眼液治療原發性開角型青光眼和高眼壓癥比拉坦前列素滴眼液具有較好的降眼壓效果及較高的安全性。

曲伏前列素滴眼液；原發性開角型青光眼和高眼壓癥；降眼壓效果；安全性

引用：朱海平，鄧德勇，謝美娜.曲伏前列素滴眼液治療原發性開角型青光眼和高眼壓癥.國際眼科雜志2016;16(12):2314-2316

0引言

現階段，臨床采用的降低眼壓的方法為0.05g/L拉坦前列素滴眼液等前列腺素制劑，由于其具有較好的降眼壓效果、較少的不良反應及用藥次數，因此在臨床得到了極為廣泛的應用[1]。曲伏前列素屬于一種新的前列腺素制劑，對FP前列腺類受體選擇性較高，具有顯著較高的效果。FP前列腺素受體激動劑降低眼壓的機制為將有效的前提條件提供給房水經葡萄膜鞏膜通路外流，因此在原發性開角型青光眼和高眼壓癥的治療中，曲伏前列素具有良好的應用效果[2]。……