532nm眼底激光聯合和血明目片治療重度NPDR的療效

陳祥雷,陶黎明,徐 媛,周 全

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·臨床研究·

532nm眼底激光聯合和血明目片治療重度NPDR的療效

陳祥雷1,陶黎明2,徐 媛1,周 全1

?METHODS: A total of 120 patients (226 eyes) diagnosed by the clinic for severe non-proliferative diabetic retinopathy diabetic retinopathy patients were randomly divided into treatment group and control group. The patients underwent combined therapy defined as treatment group (Group A), the treatment process and took He xue ming mu tablets orally for 1-3mo defines a separate line. The patients with laser photocoagulation treatment as the control group (Group B). After 1, 2 and 3mo after treatment, the retinal hemorrhage and visual function of the patients in the two groups were observed, and the fundus fluorescein angiography in 3mo after treatment was observed.

?RESULTS: Two groups of patients in the different treatment measures were taken after 1-2mo, patients suffering from eye visual function recovery was significantly better than the control group (P<0.05). But up to 2mo after the treatment, the treatment group and the control group eyes visual function index was no significant difference. Compared with the control group, the patients in the treatment group had significant advantages in terms of retinal hemorrhage, exudation, edema and fundus (P<0.05).

?CONCLUSION: The severe non-proliferative diabetic retinopathy diabetic retinopathy treated by laser combined with He xue ming mu tablets treatment, can effectively shorten the eyes with visual function recovery speed, and can promote the absorption of retinal hemorrhage and exudation rate, reduce the secondary damage to the laser has a certain role.

目的：觀察532nm眼底激光聯合和血明目片治療患有重度非增殖性糖尿病視網膜病變(non proliferative diabetic retinopathy, NPDR)患者的療效。

方法：納入經門診確診為重度NPDR患者120例226眼，采用隨機數字表分為治療組和對照組。治療組采取全視網膜光凝術聯合口服和血明目片3mo，而對照組只行全視網膜激光光凝治療。分別觀察光凝術后的1、2、3mo時兩組患者視功能、眼底視網膜出血、滲出、水腫等情況，同時記錄兩組患者光凝術后3mo眼底熒光血管造影情況。

結果：兩組患者在光凝治療術后1、2mo時，治療組患者患眼視功能恢復情況顯著優于對照組,差異具有統計學意義(P<0.05)。光凝術后3mo時，治療組與對照組患眼視功能指標之間卻無顯著性區別，但與對照組相比，治療組患者在眼底滲出、視網膜出血以及水腫消退方面具有顯著性優勢, 差異具有統計學意義(P<0.05)。

結論：對重度NPDR患者采用激光聯合和血明目片進行治療，可有效地縮短患眼視功能指標恢復速度，并可以促進視網膜出血及滲出的吸收速度，減少激光繼發再損傷有一定的作用。

糖尿病視網膜病變；視網膜光凝術；和血明目片

引用：陳祥雷,陶黎明,徐媛,等.532nm眼底激光聯合和血明目片治療重度NPDR的療效.國際眼科雜志2016;16(12):2268-2271

0引言

糖尿病視網膜病變(diabetic retinopathy，DR)是一種嚴重受累視功能的糖尿病眼并發癥，是導致20～60歲具有勞動力人群失明的主要眼病[1]。相關流行病學調查發現，DR患病率與DM病程之間呈正相關。近期美國相關學者研究證實，40歲以上的糖尿病患者中超過70%患者并發DR，并且每年因增殖期DR而導致失明的患者可達3～4萬人[2]。目前，臨床上針對DR患者采用激……