生化指標對中老年人群白內障發病的影響

周 洋，任鵬曉，梁 勇

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·臨床研究·

生化指標對中老年人群白內障發病的影響

周 洋，任鵬曉，梁 勇

?METHODS: A total of 132 patients with cataract from Jan. 2014 to Jan. 2016 in our hospital were collected as the observation group. And 156 patients besides cataract were chosen as the control group. All entrants were divided into group A (40-59y), group B (60-79y) and group C (≥80y) according to the age. The biochemical indexes of all entrants were checked, including ALB, GLB, TP, GLU, BUN, UA, Cr, ALT, LDH, ALP, TC, Ca, Na, K and P. And all indicators were given phase relationship analysis.

?RESULTS:There were no statistically significant in the level of ALP, ALT, K, P, LDH between observation group and control group. The level of ALB, GLB, TP, GLU, BUN, Cr, TC, Ca, Na in observation group were higher than those in the control group. The results of Logistic regression between two groups were as follow the level of ALB, GLU, BUN, Cr, Ca might be enrolled as risk factors for cataract. In group A, the level of ALB, GLU, Na in observation group were higher than those in the control group. In group B, the level of ALB, BUN, Cr, GLU, Na in observation group were higher than those in the control group. In group C, the level of BUN, Cr, GLU, Na in observation group were higher than those in the control group (P<0.05).

?CONCLUSION: The level of ALB, TP, BUN, Cr, TC, Ca was significantly increased which suggested that those change might associate with the pathogenesis of cataract.

目的：探討生化指標對中老年人群白內障發病的影響。

方法：選擇2014-01/2016-01間我院診治的132例244眼中老年白內障患者作為觀察組，并選擇同期我院收治的156例312眼非白內障患者作為對照組。根據所有入選者年齡的不同分為3個亞組,其中40～59歲為A組,60～79歲為B組,80歲以上為C組。檢測所有入選者的血液生化指標，主要包括周血白蛋白(ALB)、球蛋白(GLB)、總蛋白(TP)、葡萄糖(GLU)、尿素氮(BUN)、尿酸(UA)、肌酐(Cr)、谷丙轉氨酶(ALT)、乳酸脫氫酶(LDH)、堿性磷酸酶(ALP)、總膽固醇(TC)、鈣離子(Ca)、鈉離子(Na)、鉀離子(K)和磷離子(P)等指標,并進行相關性分析。

結果：兩組患者的ALP、ALT、K、P、LDH水平差異無統計學意義(P>0.05)；而觀察組患者的ALB、GLB、TP、GLU、BUN、Cr、TC、Ca、Na水平顯著高于對照組，差異有統計學意義(P<0.05)。經多因素分析發現，ALB、GLU、BUN、Cr、Ca與白內障的發生發展存在顯著相關性。以年齡組為單位分析結果顯示：A組中觀察組患者的ALB、GLU、Na水平顯著高于對照組，差異有統計學意義(P<0.05)；B組中白內障患者的ALB、BUN、Cr、GLU、Na水平顯著高于對照組，差異有統計學意義(P<0.05)；C組中白內障患者的BUN、Cr、GLU、Na水平顯著高于對照組，差異有統計學意義(P<0.05)。

結論：中老年白內障患者外周血中ALB、TP、BUN、Cr、TC、Ca水平均顯著升高，這些變化可能與白內障病變存在著一定的關聯性。

白內障；生化指標；中老年

引用：周洋，任鵬曉，梁勇.生化指標對中老年人群白內障發病的影響.國際眼科雜志2016;16(12):2244-2246

0引言

白內障是一種由各種原因引起患者晶狀體透明度下降為特征的眼部疾病，在中老年人群中較為常見，是引起患者視力下降、甚至失明的主要原因，對患者的生活質量產生嚴重不良影響[1]。據相關調查顯示我國40歲以上人群白內障的患病率達到20%以上[2]。近年來，隨著我國人口老齡化進程的加快，其患病率呈現不斷上升的趨勢，給患者家庭以及社會增加了巨大的負擔，已成為一個嚴重的公共衛生問題。目……