維生素A聯合重組人促紅細胞生成素預防早產兒貧血的療效

王 彤，張昆艷，張建麗

(河北省唐山市婦幼保健院新生兒科，唐山 063000)

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維生素A聯合重組人促紅細胞生成素預防早產兒貧血的療效

王 彤，張昆艷，張建麗

(河北省唐山市婦幼保健院新生兒科，唐山 063000)

目的 在給予重組人促紅細胞生成素的基礎上，觀察口服維生素A預防早產兒貧血的效果。方法 選取120例早產兒，分成3組，對照組給予常規治療，觀察A組給予重組人促紅細胞生成素(rHu-EPO)及維生素D滴劑，觀察B組給予重組人促紅細胞生成素及維生素AD滴劑。3組患兒均在出生后第14天開始給予維生素E、賴氨肌醇維生素B12及依地酸鐵鈉口服溶液，療程共4周；對比3組早產兒治療前后體質量、血紅蛋白(Hb)、紅細胞比容(Hct)、血清鐵蛋白(SF)及網織紅細胞(Ret)的變化情況，統計其輸血例數。結果 治療后，患兒Hb、Hct、Ret水平及輸血例數各組間均有顯著差異(P<0.05)；其SF水平觀察B組高于觀察A組及對照組(P<0.05)，觀察A組與對照組無顯著差異；觀察組W水平顯著高于對照組(P<0.05)，但觀察A組及B組間差異不明顯。結論 在給予重組人促紅細胞生成素的基礎上加用維生素A能有效地預防早產兒貧血。

維生素A；重組人促紅細胞生成素；早產兒；貧血

A.stract:Objective To observe the effect of vitamin A combined with recombinant human erythropoietin on the prevention of the anemia of prematurity.Methods Totally 120 premature infants who were born in our hospital were randomly divided into 3 groups according to voluntary principle of parents.Babies in all groups were given vitamin E,lysine，inosite and vitamin B12Oral Solution，Ferric Sodium Edentate Oral Solution when they were 14 days old，and the treatment course was 4 weeks.The observation group A were treated with recombinant human erythropoietin and vitamin D.The observation group B were treated with recombinant human erythropoietin and vitamin AD.The weight(W)，hemoglobin(Hb)，hematocrit(HCT)，serum iron (SF) reticulocyte(Ret) and blood transfusion cases were observed and recorded at the beginning and the end of the treatment.Results After treatment，Hb，HCT、Ret and blood transfusion cases were significantly different among the groups(P<0.05)；SF in the observation group B was significantly high compared with the other 2 groups，but no significant difference between the observation group A and the control group(P<0.05)；W in the observation group was significantly higher than that in the control group(P<0.05)，but no significant difference between the observation group A and the observation group B.Conclusion Vitamin A combined with recombinant human erythropoietin can effectively control the anemia of prematurity.

貧血是早產兒易出現的并發癥，尤其是胎齡偏小、體質量偏輕的早產兒，出現的時間更早、病情更重[1]。我國早產兒出生率達8.1%[2]。在各種原因住院的早產兒中，出生后貧血發生率約在40%左右[3]。造成存活早產兒貧血的原因較多，除疾病所致的貧血外，各種營養物質的缺乏造成的營養性貧血最為多見。本文旨在研究在給予重組人促紅細胞生成素的基礎上加用維生素A預防早產兒貧血的效果。

1 資料與方法

1.1 一般資料 選取2014年6月～12月在我院出生的120例存活的早產兒作為研究對象，其中男嬰52例，女嬰68例；胎齡28～36周，平均胎齡33.4±2.7周；……