核膜的動態變化與細胞增殖調控/課題立項報告

張傳茂 滕俊琳 蔣青

摘 要：細胞核內外通過核膜進行著廣泛的物質信息交流，這種交流對細胞基因的表達直至整個細胞生命活動均起著重要的調控作用。核膜的功能及細胞增殖調控研究是細胞生物學的前沿科學。核膜蛋白與核膜功能發揮及細胞增殖調控密切相關，其功能異常將導致人類重大疾病。該課題將圍繞核膜動態變化及核膜功能中的關鍵科學問題，深入研究核膜融合及核孔復合體裝配的分子基礎和機理。主要研究內容包括參與核膜組裝的關鍵蛋白，如，RanGTPase及其結合和調控蛋白、Importin-beta、Nucleoplasmin、HP1、LBR、Crm1、Pericentrin等在核膜動態變化中的作用，了解核膜膜泡的募集、融合以及核孔復合體裝配的分子機制。

關鍵詞：核膜 核孔復合體 細胞增殖

The Nuclear Envelope Dynamics and the Cell Proliferation Regulation /Project Report

Zhang Chuanmao Teng Junlin Jiang Qing

（Peking University）

Abstract：The material exchange between inside and outside of the nucleus，which is mainly through the nuclear envelope （NE）， is important for the gene expressions and cell life. The NE proteins play crucial roles for the NE dynamics，the NE functions and the cell proliferation.Dysfunctions of the NE proteins are highly related to disorders of the NE dynamics and result in severe diseases.This project will mainly focuse on the the NE dynamics and functions， and the molecular mechanisms of the NE and nuclear pore complex assembly by investigating the functions of the key proteins in NE and nuclear pore complex assembly processes， including Ran GTPase and associated proteins， importin-beta， nucleoplasmin， HP1， LBR， Crm1 and pericentrin etc.

Key Words：Nuclear envelope； Nuclear membrane； Nuclear pore complex； Cell proliferation

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