丹參酮ⅡA璜酸鈉注射液治療腦梗死的臨床療效觀察

劉榮啟

【摘要】 目的：觀察并分析丹參酮ⅡA璜酸鈉注射液治療腦梗死的臨床效果。方法：選取2011年1月-2014年1月本院診治的62例腦梗死患者的臨床資料，按照完全隨機法1：1分成對照組和研究組各31例，對照組行常規西醫對癥治療，研究組在對照組基礎上加用丹參酮ⅡA璜酸鈉注射液，觀察比較兩組患者的神經功能與生活能力改善，自由基與血液流變學指標水平變化情況。結果：與治療前比較，兩組治療后的SOD活性均明顯升高，MDA與LPO水平均明顯降低（P<0.05）。研究組治療后的SOD活性（5.96±0.13）U/mL明顯高于對照組的（4.85±0.11）U/mL，MDA水平（8.36±0.93）mmol/mL與LPO水平（10.57±2.16）mmol/mL均明顯低于對照組（10.54±0.52）mmol/mL和（13.25±2.61）mmol/mL，差異均有統計學意義（P<0.05）。治療2周、4周時，兩組NIHSS、NDS評分均明顯降低，ADL、BI評分均明顯升高，且同期組間比較差異顯著，均有統計學意義（P<0.05）；研究組治療后的全血比粘度、血漿比粘度與紅細胞聚集指數均明顯低于治療前與同期對照組，差異均有統計學意義（P<0.05）。結論：丹參酮ⅡA璜酸鈉注射液治療腦梗死的臨床效果顯著，值得臨床推廣與應用。

【關鍵詞】 丹參酮ⅡA璜酸鈉； 腦梗死； 神經功能缺損程度； 臨床效果

The Observation on Clinical Efficacy of Tanshinone ⅡA Sulfoacid Sodium Injection in Treatment of Cerebral Infraction/LIU Rong-qi.//Medical Innovation of China，2014，11（28）：111-114

【Abstract】 Objective：To observe and analyze the clinical effect of tanshinone ⅡA sulfoacid sodium injection in treatment of cerebral infraction.Method：62 patients with cerebral infraction treated in our hospital from January 2011 to January 2014 were selected and divided into the research group and the control group according to completely randomized method 1：1，31 cases in each group.The control group was treated with routine Western Medicine，the research group was treated with tanshinone ⅡA sulfoacid sodium injection on the basis of control group，the neurological function and improvement of viability，free radical and hemarheology indicators change of the two groups were observed and compared.Result：Compared with before treatment，the SOD activity of two groups after treatment were significantly higher，MDA and LPO levels were significantly decreased（P<0.05）.The SOD activity of research group after treatment was（5.96±0.13）U/mL，it was significantly higher than （4.85±0.11）U/mL of control group，the MDA level was （8.36±0.93）mol/mL and LPO level was （10.57±2.16）mol/mL，they were significantly lower than （10.54±0.52）mol/mL and （13.25±2.61）mol/mL control group，the differences were statistically significant（P<0.05）.When the patients were treated for 2 weeks and 4 weeks，NIHSS and NDS score of two groups reduced，and ADL and BI score increased，and the differences between two groups were evident，which had statistical significance（P<0.05）.The whole blood relative viscosity，plasma specific viscosity and aggregation index of red cells after treatment of the research group were significantly lower than those of before treatment and control group，the differences were statistically significant（P<0.05）.Conclusion：Tanshinone ⅡA sulfoacid sodium injection in treatment of cerebral infraction has evident clinical effect，which is worthy of clinical promotion and application.endprint

【Key words】 Tanshinone ⅡA sulfoacid sodium injection； Cerebral infraction； Neurological impairment degree； Clinical effect

First-authors address：Huangyu Public Health Center of Guanshan，Suining 221224，China

doi：10.3969/j.issn.1674-4985.2014.28.038

腦梗死（又稱缺血性腦卒中）是一種常見的腦血管疾病，具有起病突然、治療時間長期且反復、見效慢等特點，發病后可導致血液循環障礙，造成腦組織缺血缺氧，刺激腦內自由基與乳酸生成，進而加劇患者的病情進展，影響患者的良好預后[1]。為探討丹參酮ⅡA璜酸鈉注射液在保護缺血損傷中的作用，提高腦梗死患者治愈好轉率，降低致殘率與致死率，本文應用丹參酮ⅡA璜酸鈉注射液治療31例腦梗死患者，并與常規西醫對癥治療行對照比較，結果報告如下。

1 資料與方法

1.1 一般資料 選取2011年1月-2014年1月本院診治的62例腦梗死患者的臨床資料，其中頭顱CT或MRI顯示梗死部位為基底節區38例，腦葉10例，丘腦4例，多發性6例，腔隙性4例；合并疾病為高血壓25例，冠心病18例，糖尿病10例，兩種以上9例。按照完全隨機法1：1將所有患者分成對照組和研究組各31例。對照組31例患者中，男21例，女10例；年齡46～76歲，平均（61.24±6.92）歲；……