他汀類藥物在急性冠狀動(dòng)脈綜合征中的抗感染作用

呂駿

【摘要】 目的：探討他汀類藥物在急性冠狀動(dòng)脈綜合征中的抗感染作用。方法：采集本院收治的進(jìn)行冠狀動(dòng)脈支架術(shù)后的120例患者，分為對(duì)照組和觀察組，觀察組先給予氯吡格雷后進(jìn)行他汀類藥物治療，而對(duì)照組直接給予氯吡格雷藥物治療，觀察期有效性及安全性。結(jié)果：觀察組患者臨床治療的總有效率為93.3%，明顯高于對(duì)照組的總有效率71.7%；兩組患者治療后，肌鈣蛋白水平均下降，但是觀察組患者下降更為明顯；觀察組患者心血管不良反應(yīng)的發(fā)生率為6.67%，較對(duì)照組有明顯降低，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：他汀類藥物在治療急性冠狀動(dòng)脈綜合征炎癥的應(yīng)用還需進(jìn)一步研究，以提高治療效果。

【關(guān)鍵詞】 他汀類藥物； 治療； 急性冠狀動(dòng)脈綜合征； 抗感染作用

Statins in Anti Infection Effect of Acute Coronary Artery Syndrome/LYU Jun.//Medical Innovation of China，2014，11（28）：046-048

【Abstract】 Objective： To investigate the anti-infection effect of statins in acute coronary syndrome. Method： 120 patients who carried out coronary stent implantation in our hospital were divided into control group and observation group. For observation group， statins treatment was performed after clopidogrel， while clopidogrel treatment was directly performed in control group. The effectiveness and safety were observed. Result： The total effectiveness of clinical treatment of observation group was 93.3%， which was significantly higher than 71.7% of the control group. After treatment， the troponin levels were lowered in both groups， while fall of the observation was much more evident. The occurrence of cardiovascular adverse reactions of the observation patients was 6.67%， which was significantly lower than that of control group. There were significant differences for indicators between the two groups. Conclusion： In order to improve the effectiveness， the treatment with statins in acute coronary syndrome needs further study.

【Key words】 Statins； Treatment； Acute coronary syndrome； Anti infection effect

First-authors address： Hubei Province Chibi City Pufang Hospital， Chibi 437300， China

doi：10.3969/j.issn.1674-4985.2014.28.016

急性冠狀動(dòng)脈綜合征（ACS）主要是由于人體中的動(dòng)脈血管出現(xiàn)粥樣硬化狀的斑塊破裂，從而使血小板粘附聚集以及凝血因子被激活形成血栓，從而出現(xiàn)一系列的血管破裂、痙攣、出血，導(dǎo)致冠狀動(dòng)脈完全或部分閉塞引發(fā)的心肌缺血、缺氧，甚至心肌梗死等危重疾病[1-2]。由此可見(jiàn)血小板在急性冠狀動(dòng)脈綜合征的發(fā)生、發(fā)展過(guò)程中有著重要的影響，因此在治療過(guò)程中，抗血小板為主要的治療目的。而在臨床中他汀類藥物在抗血小板的應(yīng)用中極其廣泛，除了能夠抗血小板凝聚，達(dá)到降脂的治療目的以外，在近期的臨床醫(yī)學(xué)研究中，發(fā)現(xiàn)他汀類藥物還能夠治療由急性冠狀動(dòng)脈綜合征引起的感染[3-4]。因此本文就對(duì)他汀類藥物在急性冠狀動(dòng)脈綜合征中的抗感染作用及其臨床運(yùn)用進(jìn)行闡述。……