冠狀動脈硬化性心臟病與血清脂聯素、網膜素、瘦素的相關性探索

劉才華+孟珂

【摘要】 目的：探討脂聯素（ADPN）、網膜素（Omentin）、瘦素（Leptin）在冠狀動脈硬化性心臟?。–HD）患者中的變化。方法：選擇健康體檢者30例作為對照組，冠狀動脈硬化性心臟病患者34例作為CHD組，冠狀動脈硬化性心臟病合并2型糖尿病患者41例作為合并組。采用雙抗體夾心法酶聯免疫吸附試驗（ELISA）檢測各組患者血清脂聯素、網膜素和瘦素含量；采用全自動血生化分析儀分別檢測各組患者空腹血清葡萄糖（FPG）、膽固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）和低密度脂蛋白（LDL-C）含量，采用免疫比濁法檢測各組患者糖化血紅蛋白（HbAlc）含量，采用化學發光法檢測各組患者空腹血清胰島素（FINS）含量，采用穩態模型評估法（HOMA-IR）計算胰島素抵抗指數。結果：CHD組、合并組的血清脂聯素、網膜素水平均明顯低于對照組（F=45.75、113.12，q=8.23～19.65，P<0.01），合并組以上指標均明顯低于CHD組（F=54.63、103.56，q=9.26、13.28，P<0.01）；CHD組、合并組血清瘦素水平均明顯高于對照組（F=35.36，q=9.12、12.34，P<0.01），合并組的血清瘦素水平明顯高于CHD組（F=52.47，q=10.42，P<0.01）。各組脂聯素、網膜素和瘦素與HOMA-IR均有相關性（P<0.01）。結論：脂聯素、網膜素、瘦素是冠狀動脈硬化性心臟病發生發展的高危因素。

【關鍵詞】 冠狀動脈硬化性心臟病； 2型糖尿?。?脂聯素； 網膜素； 瘦素

The Study on the Relations between the Level of ADPN，Omentin，Leptin in Blood Serum for Patients with Coronary Artery Heart Disease/LIU Cai-hua，MENG Ke.//Medical Innovation of China，2014，11（28）：031-033

【Abstract】 Objective：To investigate the level change of Adiponectin （ADPN），Omentin，Leptin in blood serum for patients with coronary artery heart disease.Method：30 healthy people in our hospital were regarded as control group，34 patients with coronary heart disease were regarded as CHD group，41 patients with coronary artery heart diseases combined with type 2 diabetes were regarded as combined group.A double antibody sandwich enzyme-linked immunosorbent assay （ELISA） was tested the level of ADPN，Omentin，Leptin in blood serum of the subjects.Automatic blood biochemical analyzer was used respectively to detect the contents of fasting serum glucose （FPG），total cholesterol（TC），triglycerides（TG），high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C），turbidimetric immunoassay was used to detect the contents of glycosylated hemoglobin （HbAlc）and chemiluminescence was used to detect the contents of fasting serum insulin （FINS） of the subjects，and IR index was estimated by homeostasis model assessment.Result：The levels of serum Adiponectin，Omentin in CHD group and combined group were significantly lower than those in control group（F=45.75，113.12，q=8.23-19.65，P<0.01），the above indexes in combined group were significantly lower than those in CHD group（F=54.63，103.56，q=9.26，13.28，P<0.01），the levels of serum Leptin in CHD group and combined group were significantly higher than those in control group（F=35.36，q=9.12，12.34，P<0.01），the level of serum Leptin in combined group was significantly higher than that in CHD group（F=52.47，q=10.42，P<0.01）.The adiponectin，leptin and omentin in each group associated with HOMA-IR were correlated（P<0.01）.Conclusion：Adiponectin，Omentin and Leptin are risk factors for coronary artery heart.endprint

【Key words】 Coronary artery heart； Type 2 diabetes mellitus； Adiponectin； Omentin； Leptin

First-authors address：The People's Hospital of Shibei District in Qingdao City，Qingdao 266033，China

doi：10.3969/j.issn.1674-4985.2014.28.011

國內外近年的研究表明，脂肪組織不僅是能量貯備器官，而且具有旺盛的內分泌功能?，F已發現，人脂肪細胞分泌幾十種脂肪細胞因子及蛋白質因子，如脂聯素、網膜素和瘦素等。這些脂肪細胞因子具有廣泛的生物學特性，能調節免疫反應，參與動脈粥樣硬化的發病過程，調節靶組織的胰島素敏感性等，脂肪組織具有類似內分泌作用，調節整個機體病理生理過程[1]。

本實驗分析了冠狀動脈硬化性心臟病組、冠狀動脈硬化性心臟病合并2型糖尿病組和健康體檢對照組血清中脂聯素、網膜素和瘦素含量，并檢測了各組空腹血清葡……