高遷移率族蛋白B1在炎癥誘導(dǎo)早期自然流產(chǎn)中的病理機(jī)制研究

【摘要】目的 探討高遷移率族蛋白B1（HMGB1）表達(dá)在炎癥因子誘導(dǎo)發(fā)生早期流產(chǎn)中的病理機(jī)制，為臨床提供參考。方法 選取2021年8月至2022年12月珠海市婦幼保健院收治的40例早期自然流產(chǎn)者作為研究組，另選取珠海市婦幼保健院同期40例選擇手術(shù)終止妊娠者為對(duì)照組進(jìn)行回顧性分析。采集兩組研究對(duì)象的胎盤組織，比較兩組研究對(duì)象胎盤組織中腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-1（IL-1）、白細(xì)胞介素-6（IL-6）水平及HMGB1表達(dá)情況，分析血清TNF-α、IL-1及IL-6與HMGB1表達(dá)的相關(guān)性。結(jié)果 研究組研究對(duì)象胎盤組織TNF-α、IL-1、IL-6水平及HMGB1表達(dá)水平高于對(duì)照組（Plt;0.05）。研究組研究對(duì)象人絨毛組織塊中TNF-α、IL-1及IL-6水平高于對(duì)照組（Plt;0.05）。研究組研究對(duì)象人絨毛滋養(yǎng)細(xì)胞平均每cm2血管形成數(shù)量多于對(duì)照組（Plt;0.05）。相關(guān)性分析顯示TNF-α、IL-1及IL-6水平與HMGB1表達(dá)呈正相關(guān)（Plt;0.05）。結(jié)論 早期自然流產(chǎn)者的機(jī)體炎癥因子及HMGB1表達(dá)水平較高，且與HMGB1表達(dá)呈正相關(guān)，屬于早期自然流產(chǎn)的重要病理基礎(chǔ)。

【關(guān)鍵詞】高遷移率族蛋白 B1；炎癥因子；早期自然流產(chǎn)；相關(guān)性

【中圖分類號(hào)】R714.21 【文獻(xiàn)標(biāo)識(shí)碼】A 【文章編號(hào)】2096-2665.2023.15.0008.04

DOI：10.3969/j.issn.2096-2665.2023.15.003

Study on pathological mechanism of high mobility group protein B1 in early spontaneous abortion induced by inflammation

FENG Jiacheng CHEN Yongmei HUANG Yuanping CHEN Hailing

（1.Department of Pathology， Zhuhai Center For Maternal and Child Health Care; 2. Department of Obstetrics， Zhuhai Center For Maternal and Child Health Care， Zhuhai， 519000， Guangdong， China）

【Abstract】 Objective To explore the pathological mechanism of high mobility group protein B1 （HMGB1） expression in early spontaneous abortion induced by inflammatory factors， and to provide clinical reference. Methods 40 cases of early spontaneous abortion admitted to Zhuhai Center For Maternal and Child Health Care from August 2021 to December 2022 were selected as the study group， and 40 cases of surgical termination of pregnancy were selected as the control group for retrospective analysis. The placental tissues of the two groups were collected， and the expressions of tumor necrosis factor-α （TNF-α）， interleukin-1 （IL-1）， interleukin-6 （IL-6） and HMGB1 in the placental tissues of the two groups were compared， and the correlation between TNF-α， IL-1， IL-6 and HMGB1 expression was analyzed. Results The levels of TNF-α， IL-1， IL-6 and HMGB1" in placental tissues of the study group were higher than those in the control group （Plt;0.05）. The levels of TNF-α， IL-1 and IL-6 in human villus tissue blocks in the study group were higher than those in the control group （Plt;0.05）. The average number of blood vessel formation per cm2 in human villus tissue blocks in the study group was higher than that in the control group （Plt;0.05）. Correlation analysis showed a positive correlation of TNF- α， IL-1 and IL-6 levels with HMGB1 expression （Plt;0.05）. Conclusion The expression levels of inflammatory factors and HMGB1" in early spontaneous abortion are higher， and are positively correlated with the expression of HMGB1 ， which is an important pathological basis of early spontaneous abortion.

【Keywords】High mobility group protein B1; Inflammation factor; Early spontaneous abortion; Correlation

自然因素導(dǎo)致的流產(chǎn)稱為自然流產(chǎn)，其中孕周12周以內(nèi)的自然流產(chǎn)屬于早期自然流產(chǎn)，病因涉及遺傳、內(nèi)分泌及免疫反應(yīng)等[1]。早期自然流產(chǎn)會(huì)給患者造成巨大的身心傷害，研究自然流產(chǎn)病理機(jī)制及尋找合理干預(yù)方式對(duì)保障產(chǎn)婦生理及心理健康有重要意義[2]。近年研究顯示，正常生殖過程中，母體可抵御外界微生物入侵引起的損傷情況，也可避免存在異源遺傳物質(zhì)胚胎出現(xiàn)的免疫排斥反應(yīng)，使胎兒能夠正常生長(zhǎng)發(fā)育[3]。……