中藥大品種婦科千金片/膠囊的研究進展

張鵬 凌勇根 白璐 何媚 吳夢瑤 張素英 龔云 楊秀偉

〔摘要〕 婦科千金片/膠囊在治療婦科疾病的中成藥領域享有盛譽。近10年來，國內醫藥工作者對婦科千金片/膠囊的基礎藥學和臨床應用進行了大量研究，結果發現婦科千金片/膠囊具有抑菌、抗炎、鎮痛、補益氣血、提高免疫力等作用。臨床單獨應用或聯合其他藥物應用能治療急慢性婦科炎癥、氣滯血瘀型原發性痛經等癥，療效確切，市場前景良好，已列入國家中藥標準化提高項目。本文對婦科千金片/膠囊及原藥材的化學成分、質量控制、現代藥理作用和臨床應用進行綜述，為其進一步的開發和利用提供參考。

〔關鍵詞〕 婦科千金片;婦科千金膠囊;原藥材;質量控制;藥理作用;臨床研究

〔中圖分類號〕R284;R285? ? ? ?〔文獻標志碼〕A? ? ? ? 〔文章編號〕doi：10.3969/j.issn.1674-070X.2022.02.004

Research progress of large variety of traditional Chinese medicine

Fuke Qianjin Tablet/Capsule

ZHANG Peng1， LING Yonggen1， BAI Lu1， HE Mei1， WU Mengyao1， ZHANG Suying1， GONG Yun1， YANG Xiuwei2*

（1. Zhuzhou Qianjin Pharmaceutical Co.， Ltd.， Zhuzhou， Hunan 412000， China; 2. State Key Laboratory of Natural and Biomimetic Drugs， School of Pharmaceutical Sciences， Peking University， Beijing 100191， China）

〔Abstract〕 Fuke Qianjin Tablet/Capsule is traditional Chinese medicine that enjoys a high reputation in the field of Chinese patent medicines for the treatment of gynecological diseases. In the past 10 years， domestic medical researchers have conducted a lot of works on the basic pharmacy and clinical application of Fuke Qianjin Tablet/Capsule， they found that Fuke Qianjin Tablet/Capsule has the effect of anti-bacterial， anti-inflammatory， analgesia， nourishing Qi and blood， and improving immunity， etc. Clinical application alone or in combination with other drugs can treat acute and chronic gynecological inflammation， Qi stagnation and blood stasis type primary dysmenorrhea， with definite curative effect and good market prospects， it has been included in the national Chinese medicine standardization improvement project. This article reviews the original medicinal materials， quality control， modern pharmacological effects and clinical applications of Fuke Qianjin Tablet/Capsule， and provides references for its further development and utilization.

〔Keywords〕 Fuke Qianjin Tablet; Fuke Qianjin Capsule; original medicinal materials; quality control; pharmacological effects; clinical research

婦科千金片是株洲千金藥業股份有限公司于20世紀70年代自主研發的婦科良藥，后被認定為國家中藥保護品種，并在原方基礎上研制了婦科千金膠囊，兩個品種均已載入2020年版《中華人民共和國藥典》，且均為國家基本藥物目錄品種。婦科千金片/膠囊由千斤拔、金櫻根、穿心蓮、功勞木、單面針、雞血藤、黨參和當歸組成。方中千斤拔祛風利濕、消瘀解毒，金櫻根清熱利濕、消腫解毒，二者合用清熱除濕之力尤著，共為君藥;穿心蓮和功勞木清熱除濕，二者合用使全方清熱解毒之力增強，單面針以其辛溫之性，可防穿心蓮、功勞木過于苦寒而傷胃，使全方藥性更趨平和，無傷正氣之虞，共為臣藥;雞血藤補血、活血、通絡，黨參補中益氣、生津養血，當歸補血活血、調經止痛，共為使藥[1]。……