Galectin-3在評估冠狀動脈疾病后心肌梗死發生和預后中的價值

羅潤發

【摘要】 目的：探討Galectin-3在評估冠狀動脈疾病后心肌梗死發生和患者預后的中的價值。方法：收集2016年1月-2017年4月收治的不穩定型心絞痛患者50例（觀察組）及穩定型CAD患者50例（對照組），觀察兩組體內Galectin-3的表達水平;再將觀察組依據Galectin-3水平分為三組，分析Galectin-3與病變血管支數的相關性，隨訪觀察各組心肌梗死發生率及預后情況。結果：觀察組吸煙患者占比、糖尿病患者占比、高密度脂蛋白、低密度脂蛋白及Galectin-3等指標均高于對照組，差異均有統計學意義（P<0.05）。隨著冠狀動脈病變支數的增多，Galectin-3水平越高。≥3支血管病變患者Galectin-3水平均高于2支血管病變患者、1支血管病變患者，差異均有統計學意義（t=7.32、11.53，P<0.001）;2支血管血管病變患者Galectin-3水平高于1支血管病變患者，差異有統計學意義（t=8.03，P<0.001）。>8.6 ng/ml組心肌梗死發生率均高于<6.6 ng/ml組、6.6～8.6 ng/ml組，差異均有統計學意義（P<0.05）。>8.6 ng/ml組死亡率均高于<6.6 ng/ml組、6.6～8.6 ng/ml組，差異均有統計學意義（P<0.05）。結論：Galectin-3可作為一種評估冠狀動脈疾病患者病情程度及預后的標記物，在臨床上具有一定的應用價值。

【關鍵詞】 冠狀動脈疾病 Galectin-3 心肌梗死 預后

[Abstract] Objective： To explore the value of Galectin-3 in evaluating the occurrence and prognosis of myocardial infarction after coronary artery disease. Method： A total of 50 patients with unstable angina pectoris （the observation group） and 50 patients with stable CAD （the control group） in our hospital from January 2016 to April 2017 were collected. Then the observation group was divided into three groups according to the level of Galectin-3. The correlation between Galectin-3 and the number of vessel branches was analyzed， and the incidence of myocardial infarction and prognosis of each group were followed up. Result： The proportion of smoking patients， diabetes patients， high density lipoprotein， low density lipoprotein and Galectin-3 in the observation group were all higher than those in the control group， the differences were statistically significant （P<0.05）. As the number of coronary artery lesions increased， the higher the Galectin-3 level. The level of Galectin-3 of patients with ≥3 vascular lesions1 vascular lesion was higher than those of patients with 2 vascular lesions and 1 vascular lesion， the differences were statistically significant （t=7.32， 11.53， P<0.001）， the Galectin-3 level of patients with 1 vascular lesion was higher than that of patients with 1 vascular lesion， the difference was statistically significant （t=8.03， P<0.001）. The incidence of myocardial infarction in >8.6 ng/ml group was higher than those in <6.6 ng/ml group， 6.6-8.6 ng/ml group， the differences were statistically significant （P<0.05）. The mortality rate in >8.6 ng/ml group was higher than that in <6.6 ng/ml group， 6.6-8.6 ng/ml group， the differences were statistically significant （P<0.05）. Conclusion： Galectin-3 can be used as a marker to evaluate the severity and prognosis of patients with coronary artery disease， and it has certain clinical application value.

綜上所述，本研究證實了Galectin-3血清水平與冠狀動脈疾病患者的疾病嚴重程度具有一定的相關性，高水平的Galectin-3表達代表著患者的預后不良，Galectin-3在冠狀動脈疾病的診斷、預后評估及靶點治療中具有一定的應用價值。

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（收稿日期：2019-11-21） （本文編輯：馬竹君）