探討氨氯地平聯合厄貝沙坦對糖尿病合并高血壓的療效及對QT離散度的影響

劉濤

[摘要] 目的 對糖尿病合并高血壓患者接受氨氯地平聯合厄貝沙坦治療的效果進行分析研究，探討其對QT離散度的影響情況，為臨床提供依據。 方法 2015年2月—2017年2月該院對104例糖尿病合并高血壓患者開展分析，分成ABC 3組，A組34例患者使用厄貝沙坦治療，B組患者34例使用氨氯地平治療，C組患者36例使用厄貝沙坦和氨氯地平治療，對3組的臨床治療效果進行對比分析。結果 A組的臨床有效率是82.35%，B組的臨床治療有效率是88.24%，C組的臨床治療有效率是100.00%，3組結果差異有統計學意義（P<0.05），AB兩組差異無統計學意義（P>0.05）。3組血糖和血壓均改善，C組比其他兩組優秀，A組比B組優秀，結果差異有統計學意義（P<0.05）。3組的QT期間，校正QT期間，QT期間離散度等指標對比在治療前沒有差異性，治療后，C組比其他兩組低，結果差異有統計學意義（P<0.05）。結論 糖尿病合并高血壓使用氨氯地平聯合厄貝沙坦治療的效果突出，患者的血壓和血糖穩定，心室肥厚情況得到了改善，臨床中應該進行推廣使用。

[關鍵詞] 氨氯地平;厄貝沙坦;糖尿病;高血壓;QT離散度

[中圖分類號] R544.1 ? ? ? ? ?[文獻標識碼] A ? ? ? ? ?[文章編號] 1672-4062（2019）09（a）-0067-02

[Abstract] Objective To study the effect of amlodipine combined with irbesartan on QT dispersion in patients with diabetes mellitus and hypertension， and to provide evidence for clinical practice. Methods From February 2015 to February 2017， 104 patients with diabetes mellitus and hypertension were analyzed in our hospital. They were divided into three groups： ABC group， 34 patients in group A were treated with irbesartan， 34 patients in group B were treated with amlodipine， and 36 patients in group C were treated with irbesartan and amlodipine. Results ?The clinical effective rate of group A was 82.35%， that of group B was 88.24%， and that of group C was 100.00%. There were statistical differences among the three groups（P<0.05）. There was no statistically significant difference between the two groups（P>0.05）. The blood sugar and blood pressure of the three groups were improved. Group C was better than the other two groups， and Group B was better than Group A. There was statistical difference in the results（P<0.05）. There was no statistically significant difference between the three groups in terms of QT interval， corrected QT interval dispersion and other indicators before treatment. After treatment， group C was lower than the other two groups， and the results were statistically significant different（P<0.05）. Conclusion Amlodipine combined with irbesartan is effective in the treatment of diabetes mellitus complicated with hypertension. Blood pressure and blood sugar are stable， and ventricular hypertrophy is improved. It should be popularized in clinic.

[Key words] Amlodipine; Irbesartan; Diabetes mellitus; Hypertension; QT dispersion

糖尿病和高血壓是比較多見的疾病，治療難度大[1]。藥物治療能夠有效的改善患者的血糖水平，降低血壓，氨氯地平和厄貝沙坦聯合治療的效果突出，受到了廣泛的關注[2]。此次該院于2015年2月—2017年2月選取了104例糖尿病合并高血壓患者開展分析，將患者分成3組進行對比，現根據研究開展以下報道。