腹腔鏡術后聯合戈舍瑞林治療巧克力囊腫的效果

李小紅

[摘要]目的 比較巧克力囊腫患者腹腔鏡術后聯合孕三烯酮與戈舍瑞林治療的臨床效果。方法 將我院2014年1月～2015年11月收治的72例巧克力囊腫患者作為觀察對象，依照隨機數字表法分為對照組（n=36）和觀察組（n=36）。兩組均給予腹腔鏡術治療，在此基礎上，對照組加用孕三烯酮，觀察組加用戈舍瑞林，對兩組患者體內激素水平、臨床療效、妊娠率進行比較。結果 在激素水平方面，兩組治療后血清卵泡刺激素（FSH）、黃體生成素（LH）、雌二醇（E2）水平顯著降低（P<0.05），但組間血清FSH、LH水平比較差異無統計學意義（P>0.05），而觀察組血清E2水平顯著低于對照組（P<0.05）。在總有效率、妊娠率方面，觀察組者均高于對照組，分別為83.3% vs.61.1%、63.9% vs.38.9%，組間比較差異有統計學意義（P<0.05）。結論 巧克力囊腫患者腹腔鏡術后聯合戈舍瑞林臨床效果更加顯著，不僅可降低患者激素水平，還可提高妊娠率，值得臨床進一步應用與借鑒。

[關鍵詞]巧克力囊腫；腹腔鏡術；孕三烯酮；戈舍瑞林；臨床效果

[中圖分類號] R713.4 [文獻標識碼] A [文章編號] 1674-4721（2018）5（b）-0095-03

Effect of Goserelin combined after laparoscopic surgery treating chocolate cyst

LI Xiao-hong

Department of Gynecology，People′s Hospital of Maoming City，Guangdong Province，Maoming 525000，China

[Abstract]Objective To compare the clinical effect of laparoscopic surgery in patients with chocolate cyst combined with Gestrinone and Goserelin treatment.Methods 72 patients with chocolate cyst treated in our hospital from January 2014 to November 2015 were selected as observation subjects and divided into control group （n=36） and observation group （n=36） according to random number table method.Both groups were given laparoscopic treatment.On this basis，the patients in the control group were given Gestrinone and the patients in the observation group were given Goserelin.The levels of hormone，clinical efficacy and pregnancy rate in both groups were statistically analyzed.Results In hormone levels，two groups of after treatment，serum follicle stimulating hormone （FSH），luteinizing hormone （LH），estradiol （E2） level were significantly decreased（P<0.05），but the groups of serum FSH，there was no significant difference between the level of LH（P>0.05），and the serum E2 level of observation group was significantly lower than the control group （P<0.05）.In terms of the total effective rate，pregnancy rate，the observation group were higher than that in the control group，the data were 83.3% vs. 61.1%，63.9% vs.38.9%，there was a significant difference between groups （P<0.05）.Conclusion The clinical effect of Goserelin for chocolate cyst patients after laparoscopic surgery is more significant，not only can reduce the hormone level of patients but also can improve the pregnancy rate，which is worthy of further application and clinical reference.

[Key words]Chocolate cyst；Laparoscopy；Gestrinone；Goserelin；Clinical effect

巧克力囊腫是子宮內膜異位癥的一種類型，發病率為50%～70%[1]，若單純給予手術治療，治愈率較低，復發率較高，因此，對希望保留卵巢功能的患者來說，多聯合藥物治療，以此鞏固治療效果[2]。現今，孕三烯酮、戈舍瑞林作為促性腺激素釋放激素類似物（GnRHa）藥物，在臨床中得到了普遍應用，且具有一定的臨床療效[3-4]。為了進一步探討孕三烯酮、戈舍瑞林的治療效果，本研究現對我院收治的巧克力囊腫患者進行探究，比較腹腔鏡術聯合孕三烯酮與戈舍瑞林治療的臨床效果，現報道如下。