JAK2/STAT3信號(hào)通路與腦缺血-再灌注損傷相關(guān)性的研究進(jìn)展

楊柳，陳蓓蕾，于海龍，李軍

(大連醫(yī)科大學(xué) 研究生院，遼寧 大連　116044)

1　腦缺血-再灌注損傷與凋亡

2　JAK2-STAT3信號(hào)通路與中樞神經(jīng)系統(tǒng)

2.1　JAK2-STAT3信號(hào)通路介紹

在大鼠中樞神經(jīng)系統(tǒng)中，JAK2在胚胎階段以高水平表達(dá)，在生長和成年期其表達(dá)逐漸降低，成年期主要分布在大腦皮層，海馬，下丘腦和小腦,STAT3的表達(dá)在不同時(shí)期較為穩(wěn)定，主要分布在皮層神經(jīng)元，紋狀體神經(jīng)元，浦肯野細(xì)胞及部分小腦顆粒細(xì)胞，在JAK家族中，JAK2特異性激活STAT3[12]。

2.2　JAK2/STAT3信號(hào)通路與神經(jīng)細(xì)胞的存活、凋亡

2.3　JAK2/STAT3信號(hào)通路與中樞神經(jīng)系統(tǒng)疾病

3　JAK2-STAT3信號(hào)通路與腦缺血-再灌注損傷

4　JAK2/STAT3信號(hào)通路在腦缺血-再灌注損傷中的研究展望

[參考文獻(xiàn)]

[11] BROOKS A J,DAI W,O’MARA M L,et al.Mechanism of activation of protein kinase JAK2 by the growth hormone receptor[J].Science,2014,344(6185):1249783.

[15] OKADA S.Conditional ablation of stat3/socs3 discloses the dual role for reactive astrocytes after spinal cord injury[J].Nat Med,2006,12(7):829.

[36] LI X,ZHAO H,TAN X,et al.Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats[J].Glia,2015,63(9):1553.

[38] SARAFIAN T A,MONTES C,IMURA T,et al.Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro[J].PLoS One,2009,5(3):e9532.

[39] STREIT W J,SEMPLEROWLAND S L,HURLEY S D,et al.Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis[J].Exp Neurol,1998,152(1):74.