尤瑞克林聯(lián)合丁苯酞對72例急性腦梗死患者血管內(nèi)皮功能及神經(jīng)功能的影響

莊清芬+蘇為謙

摘 要 目的：研究尤瑞克林聯(lián)合丁苯酞治療急性腦梗死的療效及其對患者血管內(nèi)皮功能及神經(jīng)功能的影響。方法：選取144例急性腦梗死患者并隨機(jī)均分為實驗組和對照組。所有患者均接受常規(guī)支持治療，對照組在此基礎(chǔ)上予以尤瑞克林治療，實驗組予以尤瑞克林聯(lián)合丁苯酞治療。比較分析兩組的臨床療效，患者治療前后的血漿一氧化氮（NO）、內(nèi)皮素-1（ET-1）含量及神經(jīng)功能缺損評分。結(jié)果：治療后，實驗組的臨床療效優(yōu)于對照組（P<0.05）；兩組患者的血漿NO均明顯升高，而血漿ET-1明顯降低，并且實驗組的NO含量高于對照組，ET-1含量低于對照組（P<0.05）；兩組患者的NIHSS、CNFDS評分均明顯下降，且實驗組下降程度優(yōu)于對照組（P<0.05）。兩組安全性差異不顯著。結(jié)論：尤瑞克林聯(lián)合丁苯酞治療急性腦梗死，能夠有效改善患者血管內(nèi)皮功能及神經(jīng)功能，療效顯著。

關(guān)鍵詞 急性腦梗死 尤瑞克林 丁苯酞 血管內(nèi)皮功能 神經(jīng)功能

中圖分類號：R743.33； R972.9 文獻(xiàn)標(biāo)識碼：A 文章編號：1006-1533（2017）21-0016-03

Effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in 72 cases of patients with acute cerebral infarction

ZHUANG Qingfen， SU Weiqian

（Department of Encephalopathy， Traditional Chinese Medicine hospital of Quanzhou， Quanzhou 362000， China）

ABSTRACT Objective： To explore the effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in the treatment of patients with acute cerebral infarction. Methods： One hundred and forty-four cases with acute cerebral infarction were randomly divided into a research group and a control group. Besides the conventional therapy， the control group was treated with urinary kallikrein and the research group with urinary kallikrein plus butylphthalide. The clinical effects， plasma nitric oxide， content of ET-1 and neurological deficit score were compared between the two groups. Results： The clinical effects were better in the research group than in the control group after treatment （P<0.05）. The content of plasma nitric oxide was improved and the content of ET-1 was decreased in the two groups. The content of plasma nitric oxide was higher while the content of ET-1 was significantly lower in the research group than in the control group （P<0.05）. The NIHSS and CNFDS scores were all decreased in both groups and the decrease was more significant in the research group （P<0.05）. There were no differences between the two groups in the incidence of adverse reactions. Conclusion： Urinary kallikrein plus butylphthalide for the treatment of patients with acute cerebral infarction can improve the endothelial and neurological functions with remarkable curative effect.

KEy WORDS acute cerebral infarction； urinary kallikrein； butylphthalide； endothelial function： neurological function

隨著人們生活方式的改變，急性腦梗死已成為常見的腦血管疾病，全國每年新發(fā)腦卒中患者約200萬人[1]。其致殘率和致死率均較高，對患者的預(yù)后影響很大。急性腦梗死發(fā)病機(jī)制復(fù)雜，但臨床尚無特效治療方法，因而阻止缺血性腦損傷、促進(jìn)恢復(fù)神經(jīng)功能至關(guān)重要[2]。溶栓治療可以快速改善缺血組織，但卻容易受到治療時間窗、顱內(nèi)出血及再灌注損傷等方面因素的限制，因此運用藥物進(jìn)行積極的抗凝、抗血小板、保護(hù)神經(jīng)和抗氧化等治療尤為關(guān)鍵。本文主要根據(jù)我科的診治經(jīng)驗，研究了尤瑞克林聯(lián)合丁苯酞治療急性腦梗死的療效，以及其對患者血管內(nèi)皮功能及神經(jīng)功能的影響，具體報道如下。endprint