廖勇 鄧春穎
【摘要】 目的:對比原發(fā)性醛固酮增多癥(Primary aldosteronism,PA)患者腎上腺B超、CT表現(xiàn)和術后病理,評價腎上腺B超和高分辨率CT連續(xù)薄層及對比劑增強掃描(HRCT+CES)對PA的定位、分型診斷價值。方法:回顧、對比45例經(jīng)手術及病理證實的PA患者的B超和HRCT定位、分型診斷結果。結果:45例PA患者中,B超和HRCT顯示腎上腺病變分別為21例(46.7%)和45例(100%),兩種檢查方式比較差異有統(tǒng)計學意義( 字2=32.73,P=0.000);在正確診斷腎上腺病變位置方面,B超與術中所見吻合10例(47.6%),HRCT與術中所見吻合43例(95.6%),兩種檢查方式比較差異有統(tǒng)計學意義( 字2=17.88,P=0.000)。HRCT對于醛固酮瘤(APA)診斷的特異度和靈敏度分別為78.6%和88.2%,正確診斷率為66.8%;對于特發(fā)性醛固酮增多癥(IHA)診斷的特異度和靈敏度分別為76.5%和71.4%,正確診斷率為47.9%。結論:B超對于PA的定位、分型診斷價值有限,CT對PA的定位、分型診斷均有重要的臨床意義,尤其是對于APA的診斷尤為重要。
【關鍵詞】 原發(fā)性醛固酮增多癥; 分型; HRCT; B超
The Contrastive Application Values of B-mode Ultrasound and HRCT in Location and Typing Diagnosis of Primary Aldosteronism/LIAO Yong,DENG Chun-ying.//Medical Innovation of China,2017,14(30):047-050
【Abstract】 Objective:To compare the B-mode ultrasonography(B-us),CT findings and postoperative pathology of patients with primary aldosteronism(PA),and to evaluate the localization and typing diagnosis of PA with adrenal B-us and high resolution CT continuous contrast slice and contrast enhanced scan(HRCT+CES).Method:The B-us and HRCT findings of diagnosis results of location and typing in 45 cases of surgically and pathologically proved PA patients were analyzed retrospectively.Result:Among the 45 cases of PA,B-us and CT showed adrenal lesions in 21 cases(46.7%) and 45 cases(100%),the difference was statistically significant( 字2=32.73,P=0.000),in the correct diagnosis of the location of adrenal lesions,B-us was consistent with intraoperative findings in 10 cases(47.6%),and CT was consistent with intraoperative findings in 43 cases(95.6%),the difference was statistically significant( 字2=17.88,P=0.000),the specificity and sensitivity of HRCT to APA were 78.6% and 88.2% respectively,and correct diagnosis rate was 66.8%,the specificity and sensitivity of IHA diagnosis were 76.5% and 71.4% respectively,and correct diagnosis rate was 47.9%.Conclusion:B-us for the localization of PA,diagnosis and type of limited value,CT localization of PA,clinical diagnosis has important significance,especially for the diagnosis of APA.
【Key words】 Primary aldosteronism; Clinical types; HRCT; B-mode ultrasonography
First-authors address:The Forth Peoples Hospital of Zigong City,Zigong 643000,China
doi:10.3969/j.issn.1674-4985.2017.30.014
原發(fā)性醛固酮增多癥(Primary aldosteronism,PA,以下簡稱原醛)是由腎上腺皮質(zhì)病變致醛固酮分泌增多而導致的綜合征,1955年由Conn首先報道,故也稱Conn綜合征[1]。該病是以水鈉潴留及液體容量擴增而引起高血壓、低血鉀為主要特征的一組臨床癥候群,血醛固酮水平升高,腎素-血管緊張素系統(tǒng)被抑制[2-6]。多數(shù)PA患者的腎上腺病變?yōu)槿┕掏觯ˋPA)或特發(fā)性醛固酮增多癥(IHA),2016年《原發(fā)性醛固酮增多癥診斷治療的專家共識》里指出APA和IHA分別占35%和60%[7]。少數(shù)患者亦可表現(xiàn)為原發(fā)性腎上腺皮質(zhì)增生(UAH)、糖皮質(zhì)激素可治性醛固酮增多癥(GRA)、異位醛固酮分泌瘤或癌、分泌醛固酮的腎上腺皮質(zhì)癌[2]。……