鼻咽分泌物EB病毒抗體聯(lián)合檢測在鼻咽癌早期診斷中的作用

李哲　劉樹佳　陳加家　周國強　翁玉玲　趙毅

【摘要】 目的：探討鼻咽分泌物EB病毒抗體聯(lián)合檢測在鼻咽癌早期診斷中的作用。方法：課題組于2015年1月-2016年6月收治的鼻咽癌患者中選取60例作為研究對象，所有患者均給予對癥治療，并在治療前后分別收集患者的鼻咽分泌物，再采用EB病毒抗體聯(lián)合檢測方法對其VCA-IgA、EA-IgG、NA1-IgA、Rta-IgG表達(dá)水平進行檢測，以分析其早期診斷價值。結(jié)果：治療后，患者的VCA-IgA、EA-IgG、Rta-IgG表達(dá)水平均明顯下降，且隨治療時間的延長逐漸下降，與治療前相比，差異均有統(tǒng)計學(xué)意義（P<0.05）。但治療前后NA1-IgA表達(dá)水平比較，差異無統(tǒng)計學(xué)意義（P>0.05）。4項指標(biāo)聯(lián)合檢測的陽性檢出率的準(zhǔn)確性為90.00%，明顯高于VCA-IgA、EA-IgG、NA1-IgA、Rta-IgG單一檢測的準(zhǔn)確性81.67%、83.33%、78.33%、80.00%，差異均有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論：鼻咽分泌物EB病毒抗體聯(lián)合檢測在鼻咽癌早期診斷中，陽性檢出率準(zhǔn)確性較高，與單一檢測指標(biāo)相比，臨床優(yōu)勢顯著，值得推廣。

【關(guān)鍵詞】 鼻咽分泌物； EB病毒抗體； 聯(lián)合檢測； 鼻咽癌； 早期診斷

Combined Detection of EB Virus Antibodies in Nasopharyngeal Secretions and Its Role in Early Diagnosis of Nasopharyngeal Carcinoma/LI Zhe，LIU Shu-jia，CHEN Jia-jia，et al.//Medical Innovation of China，2017，14（30）：001-004

【Abstract】 Objective：To investigate the role of combined detection of EB virus antibodies in nasopharyngeal secretions in the early diagnosis of nasopharyngeal carcinoma（NPC）.Method：60 patients with NPC treated from January 2015 to June 2016 were selected by the research group as research targets，and all the patients were given corresponding treatment according to their specific symptoms.The patients nasopharyngeal secretions before and after treatment were collected and a joint assay of nasopharyngeal secretions EB virus antibody were carried out in terms of their expressive levels in VCA-IgA，EA-IgG，NA1-IgA and Rta-IgG to analyze its clinical value in the early diagnosis of NPC.Result：After treatment，the expression levels of VCA-IgA，EA-IgG and Rta-IgG in patients decreased significantly，and gradually decreased with the extension of treatment time，compared with before treatment，the differences were statistically significant（P<0.05）.However，there was no significant difference in the expression level of NA1-IgA between before and after treatment（P>0.05）.The accuracy of the positive detection rate of 4 indicators was 90.00%，significantly higher than 81.67%，83.33%，78.33%，80.00% of VCA-IgA，EA-IgG，NA1-IgA，Rta-IgG，the differences were statistically significant（P<0.05）.Conclusion：Nasopharyngeal secretion EB virus antibody combined detection in the early diagnosis of nasopharyngeal carcinoma，the positive rate of accuracy is higher，compared with the single detection index，the clinical advantages are significant，it is worth promoting.

【Key words】 Nasopharyngeal secretions； EB virus antibody； Joint detection； NPC； Early diagnosis

First-authors address：Wanjiang Hospital of Dongguan City，Dongguan 523040，Chinaendprint

doi：10.3969/j.issn.1674-4985.2017.30.001

迄今為止，鼻咽癌的具體發(fā)病原因及致病機制尚未完全闡明，但其發(fā)病率卻呈逐年上升趨勢[1]。越來越多的研究發(fā)現(xiàn)，鼻咽癌患者中的EB病毒感染率較高，甚至普遍[2-3]。對此，有學(xué)者認(rèn)為，EB病毒或許與鼻咽癌的發(fā)生、進展及預(yù)后有關(guān)[4]。并且，關(guān)于EB病毒與鼻咽癌的關(guān)系已引起了人們的廣泛關(guān)注，是目前此領(lǐng)域的研究熱點[5]。鑒于此，本研究在“EB病毒感染或可誘發(fā)鼻咽癌”論點的基礎(chǔ)上，采用EB病毒抗體聯(lián)合檢測60例鼻咽癌患者的鼻咽分泌物，進而探討其鼻咽分泌物EB病毒抗體聯(lián)合檢測在鼻咽癌早期診斷的作用。現(xiàn)報道如下。

1 資料與方法

1.1 一般資料 本研究所選的60例研究對象，均為2015年1月-2016年6月收治的鼻咽癌患者，納入標(biāo)準(zhǔn)：（1）所有患者均經(jīng)病理證實為鼻咽癌患者[6]；……