動態檢測PCT與hs—CRP在全身和局部細菌感染性疾病診斷中的臨床研究

王穎

【摘要】 目的：研究與觀察動態檢測PCT與hs-CRP在全身和局部細菌感染性疾病診斷中的臨床作用。方法：選取2015年6月-2016年11月本院的診治的56例全身細菌感染患者為A組，56例局部細菌感染者為B組，56名健康者為C組，比較A、B組治療前和治療后12 h、1 d、3 d、5 d及7 d時和C組的血清PCT與hs-CRP水平與陽性率。結果：A組、B組治療前和治療后12 h、1 d、3 d、5 d及7 d的血清PCT與hs-CRP水平與陽性率均高于C組，且A組的血清PCT與hs-CRP水平與陽性率均高于B組，A組與B組治療后的血清PCT與hs-CRP水平與陽性率均持續降低，治療后1、3、5及7 d的血清水平與陽性率均低于治療前和治療后12 h，差異均有統計學意義（P<0.05）。結論：PCT與hs-CRP在全身和局部細菌感染性疾病的診斷與區別中具有較高的價值，且其動態變化對于疾病的發展轉歸與治療指導有積極的臨床意義。

【關鍵詞】 動態檢測； PCT； hs-CRP； 全身細菌感染； 局部細菌感染

【Abstract】 Objective：To study and observe the clinical role of PCT and hs-CRP dynamic detection in the diagnosis of systemic and local bacterial infectious diseases.Method：From June 2015 to November 2016，56 patients with systemic bacterial infection in our hospital were selected as the group A，56 patients with local bacterial infection were selected as the group B，56 healthy persons were selected as group C，then the serum PCT and hs-CRP levels and positive rates of group A and group B before the treatment and at 12 hours，1st，3rd，5th and 7th day after the treatment and group C were compared.Result：The serum PCT and hs-CRP levels and positive rates of group A and group B before the treatment and at 12 hours，1st，3rd，5th and 7th day after the treatment were all higher than those of group C，the serum PCT and hs-CRP levels and positive rates of group A were all higher than those of group B，the serum PCT and hs-CRP levels and positive rates of group A and group B all continuously decreased，and the serum levels and positive rates at 1st，3rd，5th and 7th day after the treatment were all lower than those before the treatment and at 12 hours after the treatment，the differences were statistically significant（P<0.05）.Conclusion： Dynamic detection of PCT and hs-CRP has high value in diagnosis and differentiation of systemic and local bacterial infectious diseases，which also has positive clinical significance for guide disease development and treatment.

【Key words】 Dynamic detection； PCT； hs-CRP； Systemic bacterial infectious diseases； Local bacterial infectious diseases

First-authors address：Traditional Chinese Medicine Hospital of Qionglai City，Qionglai 611530，China

doi：10.3969/j.issn.1674-4985.2017.25.015

細菌感染性疾病是由細菌感染導致的疾病，當機體抵抗力降低時，免疫防御功能功能變差，病原菌侵入機體，導致感染的發生，而此類感染可分為全身與局部感染，對患者機體的影響部位與影響程度也存在一定差異[1]。同時感染可導致患者的炎性相關指標應激性變化，對于此類指標的研究與掌握是對感染存在與否及嚴重程度的必要基礎。臨床中對于感染具有較高敏感度的指標較多，其中hs-CRP作為臨床常見的一類急性時相反應蛋白，其在各類感染患者中的異常表達程度較高，而近年來臨床中關于PCT的研究不斷增多，較多研究認為PCT在感染反應中的敏感度甚至高于hs-CRP[2-3]。動態檢測PCT與hs-CRP是更為有效地反映機體感染狀態實時變化的方式，對于感染的診斷與治療有積極的臨床意義。因此，本研究中筆者就動態檢測PCT與hs-CRP在全身和局部細菌感染性疾病診斷中的臨床作用進行研究，現報道如下。……