甲潑尼龍琥珀酸鈉耳后注射治療伴2型糖尿病突發性耳聾的臨床效果

劉慧巧　陶靜　湯劍芳

[摘要] 目的 探討伴2型糖尿病突發性耳聾患者應用甲潑尼龍琥珀酸鈉耳后注射治療的臨床效果。 方法 對我院2015年10月～2017年4月期間收治的88例伴2型糖尿病突發性耳聾患者進行分組研究，根據隨機原則分為對照組和觀察組，每組各44例。對照組患者予以地塞米松鼓室內注射治療，觀察組患者予以甲潑尼龍琥珀酸鈉耳后注射治療，對兩組患者的臨床療效、各頻率聽閾改善情況及血糖控制情況進行統計對比。 結果 觀察組治療總有效率為95.5%，明顯高于對照組的77.3%，差異有統計學意義（P<0.05）。治療后，在0.5 kHz、1.0 kHz、2.0 kHz、4.0 kHz方面，觀察組聽閾改善情況均優于對照組，差異有統計學意義（P<0.05）。治療后，在空腹血糖、餐后2 h血糖方面，兩組比較差異無統計學意義（P>0.05）。 結論 甲潑尼龍琥珀酸鈉耳后注射治療伴2型糖尿病突發性耳聾的臨床效果確切，可明顯改善患者的聽閾情況，值得臨床推廣應用。

[關鍵詞] 突發性耳聾；2型糖尿病；甲潑尼龍琥珀酸鈉；耳后注射

[中圖分類號] R587.1；R764.437 [文獻標識碼] B [文章編號] 1673-9701（2017）24-0082-03

[Abstract] Objective To investigate the clinical effect of retroauricular injection of methylprednisolone sodium succinate in the patients with type 2 diabetes mellitus complicated with sudden deafness. Methods 88 patients with type 2 diabetes mellitus complicated with sudden deafness who were admitted to our hospital from October 2015 to April 2017 were divided into groups. According to the randomized principle， the patients were divided into control group and observation group， with 44 cases in each group. The patients in the control group were given intravesical injection of dexamethasone， and the patients in the observation group were given retroauricular injection of methylprednisolone sodium succinate. The clinical efficacy， the improvement of the frequency of hearing threshold and blood glucose control were statistically analyzed and compared between the two groups. Results The total effective rate was 95.5% in the observation group， which was significantly higher than that in the control group（77.3%）， and the difference was statistically significant（P<0.05）. After treatment， in terms of 0.5 kHz， 1.0 kHz， 2.0 kHz， 4.0 kHz， the hearing threshold improvement in the observation group was better than that in the control group， and the difference was statistically significant（P<0.05）. After treatment， in terms of fasting blood glucose and 2 h postprandial blood glucose， the differences were no statistically significant between the two groups（P>0.05）. Conclusion The clinical effect of retroauricular injection of methylprednisolone sodium succinate in the treatment of type 2 diabetes mellitus complicated with sudden deafness is exact， which is able to significantly improve the hearing threshold of the patients， and is worthy of clinical promotion and application.

[Key words] Sudden deafness；Type 2 diabetes mellitus；Methylprednisolone sodium succinate；Retroauricular injection

突發性耳聾指的是突然發生的、原因不明的感音神經性聽力損失，臨床表現主要有單側聽力下降，同時伴有惡心、嘔吐、耳鳴、眩暈及耳堵塞感等癥狀，屬于耳鼻喉科急癥，應給予快速及時的治療，合理用藥[1]。目前，多數醫師均認可激素治療效果。但是針對伴2型糖尿病突發性耳聾患者而言，激素不能全身應用，既往臨床多采用鼓室內局部注射，盡管具有一定的治療效果，但易發生鼓室內纖維組織增生、瘢痕粘連等情況，致使治療效果受到影響。因此，應積極探索更加有效、安全的治療方法[2，3]。本文通過對我院2015年10月～2017年4月期間收治的88例伴2型糖尿病突發性耳聾患者的分組研究，探討甲潑尼龍琥珀酸鈉的治療效果，并提出有效的護理對策，現報道如下。……