甲潑尼龍琥珀酸鈉耳后注射治療伴2型糖尿病突發(fā)性耳聾的臨床效果

劉慧巧　陶靜　湯劍芳

[摘要] 目的 探討伴2型糖尿病突發(fā)性耳聾患者應(yīng)用甲潑尼龍琥珀酸鈉耳后注射治療的臨床效果。 方法 對(duì)我院2015年10月～2017年4月期間收治的88例伴2型糖尿病突發(fā)性耳聾患者進(jìn)行分組研究，根據(jù)隨機(jī)原則分為對(duì)照組和觀察組，每組各44例。對(duì)照組患者予以地塞米松鼓室內(nèi)注射治療，觀察組患者予以甲潑尼龍琥珀酸鈉耳后注射治療，對(duì)兩組患者的臨床療效、各頻率聽(tīng)閾改善情況及血糖控制情況進(jìn)行統(tǒng)計(jì)對(duì)比。 結(jié)果 觀察組治療總有效率為95.5%，明顯高于對(duì)照組的77.3%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，在0.5 kHz、1.0 kHz、2.0 kHz、4.0 kHz方面，觀察組聽(tīng)閾改善情況均優(yōu)于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，在空腹血糖、餐后2 h血糖方面，兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。 結(jié)論 甲潑尼龍琥珀酸鈉耳后注射治療伴2型糖尿病突發(fā)性耳聾的臨床效果確切，可明顯改善患者的聽(tīng)閾情況，值得臨床推廣應(yīng)用。

[關(guān)鍵詞] 突發(fā)性耳聾；2型糖尿病；甲潑尼龍琥珀酸鈉；耳后注射

[中圖分類(lèi)號(hào)] R587.1；R764.437 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2017）24-0082-03

[Abstract] Objective To investigate the clinical effect of retroauricular injection of methylprednisolone sodium succinate in the patients with type 2 diabetes mellitus complicated with sudden deafness. Methods 88 patients with type 2 diabetes mellitus complicated with sudden deafness who were admitted to our hospital from October 2015 to April 2017 were divided into groups. According to the randomized principle， the patients were divided into control group and observation group， with 44 cases in each group. The patients in the control group were given intravesical injection of dexamethasone， and the patients in the observation group were given retroauricular injection of methylprednisolone sodium succinate. The clinical efficacy， the improvement of the frequency of hearing threshold and blood glucose control were statistically analyzed and compared between the two groups. Results The total effective rate was 95.5% in the observation group， which was significantly higher than that in the control group（77.3%）， and the difference was statistically significant（P<0.05）. After treatment， in terms of 0.5 kHz， 1.0 kHz， 2.0 kHz， 4.0 kHz， the hearing threshold improvement in the observation group was better than that in the control group， and the difference was statistically significant（P<0.05）. After treatment， in terms of fasting blood glucose and 2 h postprandial blood glucose， the differences were no statistically significant between the two groups（P>0.05）. Conclusion The clinical effect of retroauricular injection of methylprednisolone sodium succinate in the treatment of type 2 diabetes mellitus complicated with sudden deafness is exact， which is able to significantly improve the hearing threshold of the patients， and is worthy of clinical promotion and application.

[Key words] Sudden deafness；Type 2 diabetes mellitus；Methylprednisolone sodium succinate；Retroauricular injection

突發(fā)性耳聾指的是突然發(fā)生的、原因不明的感音神經(jīng)性聽(tīng)力損失，臨床表現(xiàn)主要有單側(cè)聽(tīng)力下降，同時(shí)伴有惡心、嘔吐、耳鳴、眩暈及耳堵塞感等癥狀，屬于耳鼻喉科急癥，應(yīng)給予快速及時(shí)的治療，合理用藥[1]。目前，多數(shù)醫(yī)師均認(rèn)可激素治療效果。但是針對(duì)伴2型糖尿病突發(fā)性耳聾患者而言，激素不能全身應(yīng)用，既往臨床多采用鼓室內(nèi)局部注射，盡管具有一定的治療效果，但易發(fā)生鼓室內(nèi)纖維組織增生、瘢痕粘連等情況，致使治療效果受到影響。因此，應(yīng)積極探索更加有效、安全的治療方法[2，3]。本文通過(guò)對(duì)我院2015年10月～2017年4月期間收治的88例伴2型糖尿病突發(fā)性耳聾患者的分組研究，探討甲潑尼龍琥珀酸鈉的治療效果，并提出有效的護(hù)理對(duì)策，現(xiàn)報(bào)道如下。……