運(yùn)動(dòng)神經(jīng)功能重建模型及機(jī)理研究

摘 要：該文圍繞目標(biāo)肌肉神經(jīng)功能重建動(dòng)物模型的建立及相關(guān)機(jī)制的探索展開(kāi)研究工作，重點(diǎn)解決感知覺(jué)功能恢復(fù)與增強(qiáng)及運(yùn)動(dòng)神經(jīng)功能重建在理論和技術(shù)上的可行性。利用神經(jīng)功能重建技術(shù)，實(shí)現(xiàn)感知覺(jué)和運(yùn)動(dòng)神經(jīng)信息源的生物增強(qiáng)或重建。利用目標(biāo)神經(jīng)分布重建方法，建立缺失運(yùn)動(dòng)神經(jīng)信號(hào)源重建的生物模型，獲取豐富的運(yùn)動(dòng)神經(jīng)信號(hào)；利用微電極（陣列）植入技術(shù)直接檢測(cè)外周神經(jīng)信號(hào)，研究獲取高質(zhì)量運(yùn)動(dòng)神經(jīng)信號(hào)的方法；在此基礎(chǔ)上探討運(yùn)動(dòng)神經(jīng)功能的生物重建與增強(qiáng)機(jī)理。

關(guān)鍵詞：神經(jīng)功能重建 動(dòng)物模型 神經(jīng)信號(hào)

Abstract：Early issues of the subject were to construct animal mode for targeted muscle reinnervation and to explore the related mechanism. Research work focused on solving functional recovery and enhancement for sensory perception and motor nerve in theory and technical. Biological enhancement or reconstruction of perception and motor nerve were realized using neural function reconstruction technology. First， the animal models were established using TMR technology to get a wealth of motor nerve signals in situation of lacking of motor nerve signal source. Then， micro-electrode （array） implanting technology that detects peripheral nerve signals directly was researched to obtain high-quality motor nerve signals. On this basis， mechanisms of motor nerve reconstruction and enhancement were discussed.

Key Words：TMR； Animal model； Nerve signal

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