宿州地區(qū)196例孕齡期多囊卵巢綜合征婦女

臨床特征分析

吳霞，周小艷，陳珊，王穎

?

宿州地區(qū)196例孕齡期多囊卵巢綜合征婦女

臨床特征分析

吳霞，周小艷，陳珊，王穎

[摘要]目的:探討多囊卵巢綜合征患者的臨床流行病學(xué)特征。方法：分析宿州地區(qū)196例育齡期多囊卵巢綜合征(PCOS)患者的臨床特征、血清學(xué)特征、超聲聲像學(xué)特征，并與同期因其他因素前來就診的168例育齡期婦女進(jìn)行比較。結(jié)果：宿州地區(qū)育齡期PCOS患者常見臨床征象依次為:月經(jīng)紊亂176例(89.8%)，不孕癥154例(78.6%)，痤瘡75例(38.2%)，肥胖71例(36.2%)，其中腹型肥胖47例(66.2%)，多毛 ：按F-G總分>6分，18例(9.2%)，按F-G總分>2分，57例(29.1%)，黑棘皮癥患者1例。PCOS患者中LH/FSH比值>2有60例(30.6%)、LH/FSH比值>1有150例(76.5%)，高雄激素血癥發(fā)生率25.5%(50例)，PCOS患者E2，LH及LH/FSH水平均高于對照組，差異有統(tǒng)計學(xué)意義(P<0.05)；隨著BMI的增加，患者的INS，TG，F(xiàn)PG，IR呈上升趨勢，與231應(yīng)作為篩查患者的指標(biāo)之一；肥胖的PCOS患者存在更嚴(yán)重的內(nèi)分泌紊亂。

[關(guān)鍵詞]多囊卵巢綜合征;育齡期；臨床特征;流行病學(xué)

Analysis of clinical characteristics of 196 childbearing age women with polycystic ovary syndrome in SuzhouWUXia,ZHOUXiao-yan,CHENShan,etal.(TheGeneralHospitalofCoalandPowerofNorthAnhui,Suzhou,Anhui234000,China)

【Abstract】Objective：To analyze the epidemiological characteristics of women with polycystic ovary syndrome (PCOS) in Suzhou region.Methods:196 cases of child-bearing age PCOS patients were analyzed in terms of clinical features,serological features,and characteristics of ultrasound sonogram,and at the same time were compared with other 168 cases of women of childbearing age who were treated for other reasons.Results:PCOS patients of childbearing age in the region had such common clinical signs as menstrual disorders (176 cases,89.8%),infertility(154 cases,78.6%),acne(75 cases,38.2%),obesity (71 cases,36.2%),of which abdominal obesity were 47 cases(66.2%).Hirsutism:FG score>6,18 cases(9.2%),FG score>2, 57 cases (29.1%).Acanthosis nigricans occurred in one patient.Those with LH/FSH ratio>2 were 60 cases(30.6%), LH/FSH ratio>1 were 150 cases(76.5%).The incidence of hyperandrogenism was 25.5% (50 cases).E2, LH and LH / FSH levels of the PCOS patients were higher than those of the controls.The differences were statistically significant(P<0.05).With the increase of BMI,the patient's INS,TG,FPG,IR took an upward trend. Compared with the 231should be used as one of the indicators for screening women with PCOS in Suzhou region.Obese PCOS patients may develop more serious endocrine disorders.

【Key words】Polycystic ovary syndrome; Childbearing age; Clinical features; Epidemiology

多囊卵巢綜合征(polycystic ovary syndrome,PCOS)是常見的婦科內(nèi)分泌疾病，病因至今未能完全闡明，危害患者終身，發(fā)病率較高。PCOS的臨床表現(xiàn)多樣，除了主要表現(xiàn)為肥胖、月經(jīng)不調(diào)、不孕、多毛和痤瘡?fù)猓€常伴隨雌激素依賴性腫瘤、心血管疾病和相關(guān)代謝失調(diào)的發(fā)生[1]。由于PCOS的異質(zhì)性，臨床表現(xiàn)的多態(tài)性，給診斷和治療帶來極大困難。本文參照歐洲人類生殖協(xié)會(ESHRE)和美國生殖醫(yī)學(xué)協(xié)會(ASRM)2003年在鹿特丹制定的診斷標(biāo)準(zhǔn)(ESHRE/ASRM標(biāo)準(zhǔn))[2]，對宿州地區(qū)196例育齡期PCOS患者的一般臨床特征、血清學(xué)特征、超聲聲像學(xué)特征進(jìn)行調(diào)查分析，旨在對本地PCOS患者的患病特點有初步了解，為本地婦女進(jìn)行PCOS患病情況調(diào)查提供參考方案。