丙戊酸鈉與左乙拉西坦治療小兒癲癇60例療效分析

【摘要】目的:比較丙戊酸鈉與左乙拉西坦治療兒童癲癇的療效。方法:將60例癲癇患兒完全隨機分為丙戊酸鈉組30例，左乙拉西坦組30例。丙戊酸鈉組應用丙戊酸鈉治療;左乙拉西坦組應用左乙拉西坦治療，觀察治療效果。結果:丙戊酸鈉組30例癲癇患兒治療后無效4例、有效20例、完全控制5例、加重1例、總有效率25例(83.4%)。左乙拉西坦組30例癲癇患兒治療后無效3例、有效18例、完全控制6例、加重3例、總有效率24例(80%)。兩組總有效率的比較差異無統計學意義，即總有效率差異吳顯著性。結論:丙戊酸鈉和左乙拉西坦均是相對有效的小兒抗癲癇治療藥物。

【關鍵詞】丙戊酸鈉;左乙拉西坦;癲癇;兒童

【中圖分類號】R729【文獻標識碼】A【文章編號】1007-8517(2010)12-009-2

【Abstract】Objective:To compare the sodium valproate and levetiracetam treatment of children with epilepsy. Methods:60 patients were randomly divided into sodium valproate in epileptic children complete 30 patients in the levetiracetam group of 30 patients. Application of sodium valproate sodium valproate group Treatment;Levetiracetam Levetiracetam treatment group were observed therapeutic effect. Results:The valproate group of 30 children with epilepsy treated 4 cases，effective in 20 cases，5 cases of complete control and increased in 1 case，the total effective rate of 25 cases(83.4%). Levetiracetam in children with epilepsy，30 patients after treatment and 3 cases，effective in 18 cases，complete control in 6 patients，increased in 3 cases，total effective rate of 24 cases(80%).The total effective rate of the difference was not statistically significant，difference between the total effective Wu significant. Conclusion:Sodium valproate and levetiracetam are relatively effective antiepileptic therapy in children.

【Key words】sodium valproate;Levetiracetam;epilepsy;children