奧沙利鉑聯合羥喜樹堿治療復發性卵巢上皮癌應用研究

【摘要】目的:探討奧沙利鉑(L-OHP)聯合羥喜樹堿(HCPT)治療復發性卵巢上皮癌的效果及毒副作用。方法:選擇我院2000年1月―2006年1月復發的卵巢上皮癌66例患者應用奧沙利鉑聯合羥喜樹堿治療，同期相同診斷52例作為對照組，應用PAC-1方案治療。療程結束后，比較分析癥狀體征、腫瘤大小、腫瘤標志物(CA125)、血常規、尿常規、肝腎功能、心電圖及毒副作用，1年和3年后隨訪存活率。結果:兩組療程結束后，治療組各指標明顯優于對照組。結論:奧沙利鉑聯合羥喜樹堿治療復發性卵巢上皮癌療效確切，使用安全，副作用少，可以替代傳統化療方法，值得臨床推廣使用。

【關鍵詞】復發性卵巢上皮癌;奧沙利鉑;羥喜樹堿

【中圖分類號】R979.1【文獻標識碼】A【文章編號】1007-8517(2010)12-023-2

Applied research of L-OHP combined with HCPT In recurrent epithelial ovarian cancer

Abstract:Objective:To investigate effects and side effects of L-OHP combined with HCPT in recurrent epithelial ovarian cancer. Methods:The patients with epithelial ovarian cancer in January 2000-2006 years，66 cases that treated by L-OHP combined with HCPT，52 cases treated by PAC-1. Results:The two groups after treatment，Treatment group are much higher than the control group. Conclusion:L-OHP combined with HCPT treatment of recurrent epithelial ovarian cancer is effective，safe，few side effects，can replace traditional chemotherapy，is worthy of clinical use.

Key words:recurrent ovarian cancer;L-OHP;HCPT