劉潔 王霄 安冬梅 盛瑛 宗剛軍



【摘要】 目的:分析117例伴有副腎動脈(ARA)的原發性高血壓患者的臨床特點。方法:回顧性分析2017年3月-2022年5月中國人民解放軍聯勤保障部隊第九○四醫院收治的399例原發性高血壓患者的臨床資料。根據腎動脈CTA檢查結果將患者分為ARA組(n=117)和非ARA組(n=282)。比較兩組一般資料、24 h動態血壓、心腎功能和腎素-血管緊張素-醛固酮系統(RAAS)指標。結果:399例原發性高血壓患者中有117例伴有ARA,占29.32%(117/399)。ARA組的男性比例、日間平均收縮壓(DA-SBP)、日間平均舒張壓(DA-DBP)、夜間平均收縮壓(NA-SBP)、夜間平均舒張壓(NA-DBP)、24 h收縮壓(24 h-SBP)、24 h舒張壓(24 h-DBP)、臥位腎素、立位腎素、臥位醛固酮、立位醛固酮和24 h尿醛固酮均高于非ARA組,差異均有統計學意義(P<0.05)。結論:伴有ARA的患者,其男性比例和血壓水平更高,RAAS更活躍。
【關鍵詞】 副腎動脈 原發性高血壓 心功能 腎功能 動態血壓
Clinical Characteristics of 117 Patients with Essential Hypertension Associated with Accessory Renal Artery/LIU Jie, WANG Xiao, AN Dongmei, SHENG Ying, ZONG Gangjun. //Medical Innovation of China, 2023, 20(11): -112
[Abstract] Objective: To analyze the clinical characteristics of 117 patients with essential hypertension associated with accessory renal artery (ARA). Method: The clinical data of 399 patients with essential hypertension admitted to the 904 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army from March 2017 to May 2022 were analyzed retrospectively. They were divided into ARA group (n=117) and non-ARA group (n=282), according to the results of renal artery CTA. The general data, 24 h ambulatory blood pressure, cardiac and renal function and renin angiotensin aldosterone system (RAAS) indexes were compared between the two groups. Result: 117 patients with ARA out of 399 patients with essential hypertension, accounting for 29.32% (117/399). The male proportion, daily average systolic blood pressure (DA-SBP), daily average diastolic blood pressure (DA-DBP), nighttime average systolic blood pressure (NA-SBP), nighttime average diastolic blood pressure (NA-DBP), 24 h systolic blood pressure (24 h-SBP), 24 h diastolic blood pressure (24 h-DBP), lying renin, standing renin, lying aldosterone, standing aldosterone and 24 h urinary aldosterone in ARA group were higher than those in non-ARA group, the differences were statistically significant (P<0.05). Conclusion: The male proportion and blood pressure in patients with ARA are higher, and the RAAS is more active.
[Key words] Accessory renal artery Essential hypertension Cardiac function Renal function Ambulatory blood pressure
First-author's address: The 904 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Wuxi 214125, China
doi:10.3969/j.issn.1674-4985.2023.11.026
高血壓是引起腦卒中、心肌梗死和心力衰竭等多種心腦血管疾病的主要危險因素之一,也是引起視網膜、腎臟等器官結構和功能損害的重要原因之一[1-2]。原發性高血壓占全部高血壓疾病的90%以上[3]。高血壓人群腎動脈CTA檢查常見副腎動脈(ARA)的存在。ARA指不經過腎門而進入腎臟的動脈,多數起自于腹主動脈,從腎的上極或下極直接入腎[4]。ARA血管較細長,走形迂曲,易導致所供腎區血液灌注不足,反射性引起腎交感神經異常激活,進一步激活腎素-血管緊張素-醛固酮系統(RAAS),導致腎血管性高血壓[5-6]。關于ARA與原發性高血壓之間的關系,既往的研究報道相當有限,且結果存在較大爭議。本研究回顧性分析2017年3月-2022年5月中國人民解放軍聯勤保障部隊第九○四醫院收治的399例原發性高血壓患者的臨床資料,以分析ARA的發生率及臨床特點。