新加香薷飲抗炎和解熱作用研究

李小讓 葉世蕓 鑒志剛 羅文艷 李向東

【摘 要】

目的：研究新加香薷飲的抗炎、解熱作用。方法：用角叉菜膠致SD大鼠炎癥模型、干酵母致SD大鼠發(fā)熱模型。觀察新加香薷飲對大鼠足腫脹度、解熱作用及其對血清中TNF-α、IL-6及下丘腦組織5-HT、NE含量。結(jié)果：抗炎作用，與空白組相比，模型組大鼠右后足跖腫脹明顯增加；與模型組比較，新加香薷飲8.05 g/kg組對大鼠足跖腫脹程度有明顯的減輕（P＜0.05）。解熱作用，與空白組相比，模型組大鼠血清中TNF-α、IL-6及下丘腦組織中5-HT含量均明顯升高（P＜0.05），下丘腦組織中NE含量明顯降低（P＜0.05）；與模型組相比，陽性組、新加香薷飲8.05 g/kg組、新加香薷飲4.05 g/kg組大鼠血清中TNF-α含量均明顯降低（P＜0.05），陽性組及新加香薷飲8.05 g/kg組血清中IL-6含量均明顯降低（P＜0.05），新加香薷飲8.05 g/kg組大鼠下丘腦中5-HT含量及陽性組大鼠下丘腦中NE含量明顯降低（P＜0.05），其余各組無明顯變化。結(jié)論：新加香薷飲有良好的抗炎、解熱作用，其機(jī)制可能是通過抑制炎癥因子TNF-α、IL-6的合成與釋放，下調(diào)下丘腦組織中5-HT含量和上調(diào)下丘腦組織中NE含量，進(jìn)而使單胺類神經(jīng)遞質(zhì)保持平衡，降低體溫及產(chǎn)熱量，起到解熱效果。

【關(guān)鍵詞】 新加香薷飲；抗炎作用；解熱作用

【中圖分類號】R285.5?? 【文獻(xiàn)標(biāo)志碼】 A??? 【文章編號】1007-8517（2023）07-0024-05

Study on the Anti-Inflammatory and Antipyretic Effects of Xinjia Elsholtzia Drink

LI Xiaorang1 YE Shiyun1* JIAN Zhigang1 LUO Wenyan1 LI Xiangdong2

1.Guizhou University of Traditional Chinese Medicine， Guiyang 550002，China;2.Guizhou Dexuantang Hukang Pharmaceutical Co.， Ltd.， Guiyang 550008，China

Abstract：

Objective To study the anti-inflammatory and antipyretic effects of Xinjia Elsholtzia drink.Methods A model of inflammation in SD rats caused by carrageenan gum and a model of fever in SD rats caused by dried yeast were used.The effects of Xinjia Elsholtzia drink on the degree of foot swelling，antipyretic effect and its effect on TNF-α and IL-6 in serum and 5-HT and NE content in hypothalamus tissue of rats were observed.Results The anti-inflammatory effect， compared with the blank group， the swelling of right hind foot and plantar of rats in the model group increased significantly；compared with the model group， the swelling of foot and plantar of rats in the Xinjia Elsholtzia 8.05 g/kg group was significantly reduced （P<0.05）;the antipyretic effect， compared with the blank group， the TNF-α and IL-6 in serum and 5-HT content in hypothalamus tissue of rats in the model group were significantly increased （P<0.05）. The content of NE in hypothalamic tissue was significantly lower （P<0.05）；Compared with the model group， the TNF-α content in the serum of rats in the positive group， Xinjia Elsholtzia 8.05 g/kg group and Xinjia Elsholtzia 4.05 g/kg group was significantly lower （P<0.05）. In the group of rats with 8.05 g/kg of Xinjia Elsholtzia， the content of 5-HT in the hypothalamus and the content of NE in the hypothalamus of rats in the positive group were significantly reduced （P<0.05）.Conclusion Xinjia Elsholtzia has good anti-inflammatory and antipyretic effects. The mechanism may be through inhibiting the synthesis and release of inflammatory factors TNF-α and IL-6，down-regulating 5-HT content in hypothalamic tissues and up-regulating NE content in hypothalamic tissues，thus keeping monoamine neurotransmitters in balance，lowering body temperature and heat production，and providing antipyretic effects.

Keywords：Xinjia Elsholtzia Drink; Anti-inflammatory Effect; Antipyretic Effect

新加香薷飲最早收錄于清代醫(yī)家吳鞠通所著《溫病條辯》［1］，由香薷、鮮扁豆花、金銀花、連翹、厚樸五味藥組成。其中香薷為君藥，金銀花、扁豆花、連翹共為臣藥，厚樸為使藥，該方具有祛濕解表，清熱化濕之功效。現(xiàn)代藥理作用闡明香薷所含的揮發(fā)油具有消炎、解熱作用［2］；……