Timely vitrectomy without intraocular lens removal for acute endophthalmitis after cataract surgery

INTRODUCTION

The mean age of all patients was 71.4y(range, 63-84y; Table 1). Five patients had a history of diabetic mellitus. All patients had symptoms of acute ocular pain and a sudden decrease of vision after cataract surgery. All patients had hypopyon, edema cornea, hyperemic and edema conjunctiva. The mean time between cataract surgery and the onset of endophthalmitis was 2d with a range from 1 to 3d.The mean follow-up period was 25.5mo with a range from 16 to 53mo.

Previous treatment methods included vitrectomy, IOL removal, and local and systemic use of antibiotics

; however,IOL removal decreases uncorrected visual acuity, leaving patients dissatisfied with the outcome, and likely leading to postoperative medical dissension. In most reports on the treatment of post-cataract endophthalmitis, the visual acuity of only half of the cases reached 20/40

. To date, there are few reports on the effect of vitrectomy on postoperative pseudophakic endophthalmitis without IOL removal.Therefore, the clinical features, causative organisms, and effects of vitrectomy and silicone oil tamponade without IOL removal in the treatment of APCE are reported here using a small case series.

SUBJECTS AND METHODS

從2004年開始，我國普通高校招收新疆高中班畢業生的工作實行“統一試卷、統一閱卷、單獨劃線、單獨招生”的辦法。2005年，國務院明確了高考錄取過程中對少數民族考生優惠錄取的政策。從2008年開始，對邊疆、山區、牧區、少數民族聚居地區的少數民族考生，由省級招生委員會決定，可在高等學校調檔分數線下適當降低分數要求投檔，由學校審查決定是否錄取。而教育部則表示少數民族高考加分政策不會改變。

This study involved a series of clinical characteristics and microbial factors in 10 eyes of 10 patients treated for APCE between January 2010 and December 2018 at Tianjin Medical University General Hospital. Post-cataract endophthalmitis is classified as APCE if it occurs within six weeks postoperatively, and chronic if it occurs after this period

. The diagnosis of APCE was the appearance of ocular pain, sudden vision decrease, conjunctival congestion and edema, corneal edema, hypopyon, and vitreous opacification after cataract surgery, regardless of whether the culture of intraocular fluid was ultimately positive

. Cases in which cataract surgery was combined with other eye surgeries were excluded. The posterior capsule had minor rupture during cataract surgery in 2 eyes, and was intact in 8 eyes. All patients received systemic antibiotics and vitrectomy combined with silicone oil tamponade, and the IOL was maintained in each eye.

The treatment indications for vitrectomy without IOL removal on APCE are as follows: 1) No abnormal changes in the implanted IOL, such as dissolution, reduced transparency, and deformation; 2) Patients with better corrected vision (＞20/40)after cataract surgery before the occurrence of endophthalmitis;3) Absence of zonular dialysis or severe rupture of the posterior capsule (＞1/4 quadrant) during cataract surgery; 4)Patients without severe systemic diseases.

神話故事最初來自民間，始于口頭創造，經過一代又一代人的傳承才得以流傳至今。在神話故事中，神鬼和英雄傳說為兩大主體，其中蘊藏著人們對美好生活的向往，對理想的不懈追求和對英雄人物的推崇與尊敬，同時也是對現實壓迫的一種反抗，因此神話故事中雖然多為不存在的事物，但其卻是對現實世界最真實、最恰當的展現，以一種理想化的方式反映社會與人心，從中可以窺見人們的真實想法[1]。因此即便神話故事脫離現實，但后世的人們仍然能夠了解當時的社會背景、人們所處的環境、生活方式、內心的狀態和追求，極具層次性且具有深刻意義，是現實與想象的結合體。

例如，學生可以根據第二次筆記中記載的有關“蛋白質”專題的知識，進行蛋白質概念圖的建構。學生在分析解決一定量的遺傳題之后總結遺傳題分析手段(方法)有兩種： 通過遺傳圖解分析與通過系譜圖分析等。

The Wilcoxon signed-rank test was used to assess the change in pre- and post-surgical IOP.

Routine topical cycloplegics (1.0% atropine sulfate) and topical corticosteroids(1.0% tobramycin dexamethasone) were administered 3 times per day for 7.0d after surgery. Systemic corticosteroids were administered orally with prednisolone at 30 mg once a day for 7.0d. Intravenous infusion of ofloxacin 100 mg twice a day for 7.0d and ofloxacin eye drops 3 times per day were then administered for 2.0wk. The routine follow-up was performed 1, 3, 5d, 1, 2, 4, 12wk, 6 and 12mo postoperatively.

All surgeries were performed under retrobulbar anesthesia (2.0% lidocaine) by the same surgeon(Yan H). An initial undiluted anterior chamber specimen was obtained for organism culture before irrigation/aspiration.The capsular bag was separated from the IOL with the use of viscoelastics. Then the anterior chamber and capsular bag were irrigated/aspirated completely and repeatedly. An initial undiluted vitreous specimen was also obtained for microbiological culture before vitrectomy. The posterior vitreous detachment from the optic disc was performed and infected vitreous was completely removed during vitrectomy.After vitrectomy, the anterior chamber and capsular bag were reirrigated/aspirated again if the anterior segment was not clear. Finally, the silicone oil was filled.

RESULTS

Although postoperative endophthalmitis is rare with an incidence of 0.02%-0.33%

, it is one of the most serious complications after cataract surgery

. If this condition is not treated in a timely manner, it may result in visual loss and even ocular atrophy. The incidence of endophthalmitis following phacoemulsification and intraocular lens (IOL)implantation is estimated to be between 0.012% and 1.3%since 2000

, and acute-onset post-cataract endophthalmitis(APCE) occurred in 0.04% cataract surgeries performed in the United States between 2013 and 2017

. Risk factors include anterior vitrectomy, cataract surgery combined with other ophthalmic surgery, younger age, intraoperative posterior capsule rupture, non-use of antibiotics, and non-use of behindthe-lens washout

.

據不完全統計，每年到林畬鄉旅游參觀的游客有5萬余人次，其中包括前來研學旅行的學生，前來接受紅色文化、廉政文化教育的群體和自駕游群體，以后還將有前來進行“醫康養”項目的老年群體等，這意味著林畬鄉的旅游產業將會逐漸壯大。……